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D. Ahmed, X. Mao, J. Shi, B. K. Juluri and T. J. Huang, Lab Chip, 2009, 9, 2738 DOI: 10.1039/B903687C

b Department of Bioengineering, The Pennsylvania State University, University Park, PA, USA

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a Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, USA E-mail: junhuang@psu.edu Fax: +814-865-9974 Tel: +814-863-4209

We present ultra-fast homogeneous mixing inside a microfluidic channelvia single-bubble-based acoustic streaming. The device operates by trapping an air bubble within a “horse-shoe” structure located between two laminar flows inside a microchannel. Acoustic waves excite the trapped air bubble at its resonance frequency, resulting in acoustic streaming, which disrupts the laminar flows and triggers the two fluids to mix. Due to this technique's simple design, excellent mixing performance, and fast mixing speed (a few milliseconds), our single-bubble-based acoustic micromixer may prove useful for many biochemical studies and applications.