BiomedicalVitamin C

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Keywords: antigen stability; dissolving microneedle characterization; dissolving microneedle fabrication; skin immunization; vaccine delivery.

Schematic representation of microneedle insertion and conventional (intramuscular, subcutaneous and intradermal) injections onto…

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The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or needle re-use). This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen. The microneedle patch fabrication techniques and their challenges are discussed as well as the microneedle characterization methods and antigen stability aspects. The immunogenicity of antigens formulated in dissolving microneedles are addressed. Finally, the early clinical development is discussed.