The heavy load of the wings makes the Gulfstream 200 fly evenly in all conditions. A long-travel trailing link landing gear smooths out taxiing and landings. Hydraulically-powered carbon anti-skid brakes and a 100º pivot radius of the nosewheel provide for excellent ground handling.

Background: Primary Sjögren's syndrome is an autoimmune disease that presents as dryness of the mouth and eyes due to impairment of the exocrine glands. To our knowledge, no systemic therapies for primary Sjögren's syndrome have shown efficacy. CD40–CD154-mediated T cell–B cell interactions in primary Sjögren's syndrome contribute to aberrant lymphocyte activation in inflamed tissue, leading to sialadenitis and other tissue injury. Therefore, we investigated the safety and preliminary efficacy of iscalimab (CFZ533), a novel anti-CD40 monoclonal antibody, in patients with primary Sjögren's syndrome. / Methods: This multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study took place at ten investigational sites across Europe (UK, n=4; Germany, Switzerland, and Hungary, n=1 each) and the USA (n=3). Eligible patients were aged 18–75 years and fulfilled the 2002 American European consensus group diagnostic classification criteria for primary Sjögren's syndrome. In the double-blind phase of the trial, patients were randomly assigned (2:1) via computer-generated unique randomisation numbers to receive subcutaneous iscalimab (3 mg/kg) or placebo at weeks 0, 2, 4, and 8 (cohort 1) or intravenous iscalimab (10 mg/kg) or placebo at weeks 0, 2, 4, and 8 (cohort 2). Randomisation was stratified according to baseline intake of oral corticosteroids. At week 12, patients in both cohorts received open-label iscalimab (same dose and route) for 12 weeks. The primary objectives of the study were to assess the safety, tolerability, and efficacy of multiple doses of iscalimab in the two sequential dose cohorts. Safety and tolerability were assessed by adverse events and efficacy of iscalimab versus placebo was assessed by clinical disease activity, as measured by the change in European League Against Rheumatism Sjögren's syndrome disease activity index (ESSDAI) score after 12 weeks of treatment. Analyses were done on a per-protocol basis. The trial was registered with ClinicalTrials.gov, NCT02291029. / Findings: Between Oct 22, 2014, and June 28, 2016, we assessed 82 patients for eligibility (25 for cohort 1 and 57 for cohort 2). 38 patients were excluded because of ineligibility. In cohort 1, 12 patients were randomly assigned to receive either 3 mg/kg doses of iscalimab (n=8) or placebo (n=4), and in cohort 2, 32 patients were randomly assigned to receive either intravenous 10 mg/kg doses of iscalimab (n=21) or placebo (n=11). Adverse events were similar between iscalimab treatment groups and placebo groups, with adverse events occurring in all patients in cohort 1, and in 52% and 64% of the iscalimab and placebo groups, respectively, in cohort 2. Two serious adverse events were reported (one case of bacterial conjunctivitis in cohort 1 and one case of atrial fibrillation in cohort 2), which were unrelated to treatment with iscalimab. Intravenous treatment with iscalimab resulted in a mean reduction of 5·21 points (95% CI 0·96–9·46; one-sided p=0·0090) in ESSDAI score compared with placebo. There was no signficiant difference in ESSDAI score between subcutaneous iscalimab and placebo. / Interpretation: To our knowledge, this is the first randomised, placebo-controlled proof-of-concept study of a new investigational drug for primary Sjögren's syndrome that indicates preliminary efficacy. Our data suggest a role of CD40–CD154 interactions in primary Sjögren's syndrome pathology and the therapeutic potential for CD40 blockade in this disease should be investigated further. / Funding: Novartis Pharma.

Fisher, BA; Szanto, A; Ng, WF; Bombardieri, M; Posch, MG; Papas, AS; Farag, AM; ... Gergely, P; + view all Fisher, BA; Szanto, A; Ng, WF; Bombardieri, M; Posch, MG; Papas, AS; Farag, AM; Daikeler, T; Bannert, B; Kyburz, D; Kivitz, AJ; Carsons, SE; Isenberg, DA; Barone, F; Bowman, SJ; Espié, P; Floch, D; Dupuy, C; Ren, X; Faerber, PM; Wright, AM; Hockey, HU; Rotte, M; Milojevic, J; Avrameas, A; Valentin, MA; Rush, JS; Gergely, P; - view fewer (2020) Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study. The Lancet Rheumatology , 2 (3) e142-e152. 10.1016/S2665-9913(19)30135-3.

The required runway distance for takeoff at sea level is 6,083 feet with standard loading, or 6,342 feet when loaded to its maximum takeoff weight (MTOW) of 35,450 pounds. At an altitude of 5,000 feet and a temperature of 77ºF, the takeoff distance increases to 9,800 feet.

Galaxy Aerospace Corp selected the Collins Pro Line 4 avionics suite for the Gulfstream 200’s cockpit. A central EICAS (Engine Indicator and Crew Alert System) screen is surrounded by four smaller screens that display flight and systems information. Standard devices include dual ARINC 429 Pro Line Communication/Navigation/Identification radios with dual DMEs and ADEs, a single AlliedSignal GNS-X/EX FMS (Flight Management System), a WXR-840 solid-state weather radar diagnostic computer, digital autopilot, digital air data and attitude/heading reference system. Practically any additional equipment can be added if desired.

It’s not every day that an early-generation private jet turns out to be such a success, but the Gulfstream 200 is a definite exception to that rule. Few other super midsize private jets can fly eight passengers 3,680 miles (3,200 nautical miles) at .80 Mach. For that matter, few first-generation private jets are so reliable. The success of the Gulfstream 200 was unanticipated by the private jet industry, and continues to perform at high standards of excellence.

Two Pratt & Whitney PW306A engines power the Gulfstream 200, each flat-rated to 6,040 pounds of thrust. These engines are very similar to the PW305 engines used successfully on the Learjet 60 and the Hawker 1000. They have the same high standards of performance but put out 785 more pounds of thrust.

The Gulfstream 200 was one of the first private jets in the Gulfstream series, jets that would become top competitors in the super-midsize category. The newly-formed Galaxy Aerospace Corp, a division of Israel Aviation Industries (IAI), became a major contender in the private jet category with the Gulfstream 200; this jet continues to compete today with the more recent G450 and G550. The Gulfstream 200 has everything that could be desired in a private jet: great range, cabin size, and speed. It’s the ideal jet for completing long-range missions rapidly and comfortably.

The cabin of the Gulfstream 200 can be configured to hold anywhere between eight and nineteen seats. The cabin itself is 24.4 feet long, 7.2 feet wide and 6.3 feet high. Optional additions include a radio phone, entertainment systems, and interior design upgrades. There are power outlets available for any piece of office equipment in addition to an outlet for each passenger. There is 125 cubic feet of baggage space available in an external compartment, able to contain up to 2,400 pounds. An added bonus of the Gulfstream 200, having been designed in the extreme temperatures of Israel, is its capacity to maintain a cool cabin. According to Galaxy Aircraft Corp, the Gulfstream 200 can cool the cabin to 75ºF on a 113ºF day. Both the cabin and the cockpit have separate climate controls, and the air in the temperature control system continually provides the passengers with fresh air instead of recirculated air.

The airframe of the Gulftstream 200 was designed to be as aerodynamic as possible with the help of 3-D computer-aided structural analysis programs. The main structures are made out of aluminum alloys, titanium, and steel; composites are used for some secondary structures. Fuel is stored in three fuel tanks – one on each wing and one in the belly of the aircraft. The fuel levels of the three tanks are automatically equalized by gravity interconnect valves.

The Gulfstream 200 can climb directly to an altitude of 37,000 feet in nineteen minutes. For a long range cruise, it travels at 430 knots at an altitude of 41,000 feet; for a high speed cruise, it travels at 470 knots (.82 Mach) at 39,000 feet. The cabin is rated to 8.9 psi, meaning it can maintain a sea level cabin at 23,000 feet, or an 8,000 foot cabin at its maximum flight level of 45,000 feet. With a range of 3,910 miles (3,400 nautical miles), the Gulfstream 200 is ideal for long-range transcontinental or transoceanic missions.