Keywords: MRSA; PbP 2a; Sulphonamides; binding mode prediction; molecular docking; molecular dynamics simulation; peptides.

Map Map | Street Street | Birds Eye Birds Eye

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Listing Courtesy of AGENT TRUST REALTY CORPORATION. For information or to schedule a viewing of this property (MLS# S5115622) located at 1025 S Hiawassee Rd # 2216 Orlando FL 32835, call: 407-278-2057

1025 S Hiawassee Rd # 2216, Orlando FL is a condo of 627 sqft and is currently priced at $160,000 . This condo has 1 bedrooms. A comparable condo for sale at 6412 Raleigh St # 2511 in Orlando is listed at $214,900. This condo on 1025 S Hiawassee Rd # 2216 has not had a price change. In addition to condos, EasyStreet also makes it easy to find Homes, Condos, New Homes and Foreclosures in Orlando, FL. Grove Park, Bermuda Dunes and Horizons Stonebridge Place are nearby neighborhoods. MLS S5115622 has been posted on this site since 11/14/2024 (today).

Privacy Policy/Legal Notices   |   Corporate Sitemap   |   Listings Sitemap

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Penicillin binding protein 2a (PbP 2a) expression accounts for the insusceptibility of methicillin-resistant Staphylocuccus aureus (MRSA) to β-lactam antibiotics. Here we employed computational strategies to challenge PbP 2a with series of fifty-five 'ala-ala' and 'ala-pro' sulphonamide-dipeptides. Binding stability of two compounds (labeled: 10i and 10n) with theoretical Ki in nM and µM ranges, for PbP 2a active and allosteric sites respectively, were investigated using molecular dynamics simulations. In addition, the results of the sensitivity of four strains of MRSA for compounds 10i and 10n obtained revealed the compounds at 10 µg/ml caused two isolates (S4 and S10) to revert to being susceptible. Finally, a reliable binding conformations of both compounds in the two binding sites of PbP 2a are described to provide rationale for structure-activity optimization of this series.Communicated by Ramaswamy H. Sarma.

We'll be in touch shortly to confirm your tour time and other details. Please let us know how to reach you.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

These statistics are updated daily from the My Florida Regional MLS. For further analysis or to obtain statistics not shown below please call EasyStreet Realty at (407) 278-2057 and speak with one of our real estate consultants.

A prime Metrowest location. Tradewinds Condominium is located in the beautiful Orlando metropolitan area. This unit has 1 bedroom with a dressing room in the bedroom, 1 bathroom, on the first floor, as well as an interior utility room that includes a washer and dryer, a porch with a storage closet. The kitchen is open to the living/dining room and has a breakfast bar and laminate in the dining area. The community offers a clubhouse, 2 pools and 2 jacuzzis, gym, racquetball court, barbecue areas, beach park and tennis courts. Conveniently minutes from major Orlando highways for quick and easy access to dining, shopping and entertainment, 15 minutes from Universal Studios, 20 minutes from Disney Parks.