Famuyide AO, Laughlin-Tommaso SK, Shazly SA, Hall Long K, Breitkopf DM, Weaver AL, et al. Medical therapy versus radiofrequency endometrial ablation in the initial treatment of heavy menstrual bleeding (iTOM trial): a clinical and economic analysis. PLoS One. 2017;12:e0188176.

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Atterby A. North American sanitary protection market, a case study: Nonwoven Industry Magazine; 2008. https://www.thefreelibrary.com/North+American+sanitary+protection+market%2C+a+case+study.-a0189794968 Accessed 17 Apr 2009

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All PBACs estimate MBL from feminine towels. Modern towels have a layered design, consisting of a fluid-permeable surface (topsheet), an absorbent core and an impermeable backing with adhesive. The shape, absorbency and size of the product may vary depending on the manufacturer. The towel contour may be either flat or curved, and with or without ‘wings’ which attach it securely in place and add extra leak protection. Menstrual fluid rapidly transfers to the absorbent core via a series of micro-funnels, leaving the upper surface relatively dry and stain free. The US Food and Drug Administration (FDA) regulates sanitary towels as Class I Medical Devices subject to manufacturing controls and consumer complaint management, but the absorbency ratings are arbitrary and unregulated. Towels of similar size and/or with the same stated absorbency category but from different manufacturers can have a wide range of fluid retention capacities [77]. In ultra-slim formulations, MBL may be captured by a thin collapsed polymeric foam layer that expands and absorbs fluid upon contact [85] or by superabsorbent polymer granules embedded in the towel core (e.g. Always Ultra). The manner of stain spread depends on the density and distribution of superabsorbent particles throughout the absorbent zone, which varies among towel brands. Modern thick maxi towels are more efficient at absorbing fluid and limiting stain spread than their former versions, as demonstrated in Fig. 4 [75], although they are generally less popular than ultra-slim products. A pictorial chart requires validation for a specific brand of feminine towel in a range of absorbencies to accommodate different levels of MBL.

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You will be able to request reasonable adjustments to the recruitment process within the application form. If you need additional help completing the application form, please contact the SSCL Recruitment Enquiries Team.

Glas AS, Lijmer JG, Prins MH, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol. 2003;56:1129–35.

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Hallberg L, Hogdahl AM, Nilsson L, Rybo G. Menstrual blood loss--a population study. Variation at different ages and attempts to define normality. Acta Obstet Gynecol Scand. 1966;45:320–51.

Pictorial blood loss assessment charts are increasingly being used in clinical trials to diagnose HMB and to evaluate efficacy of new treatments, despite the fact that, in most cases, their accuracy has not been validated with modern sanitary materials. We have highlighted some key factors to consider when using this method in the contemporary research setting. We hope that this review will act as a basic guide for researchers who wish to use a PBAC to assess MBL, whether for selection of the most appropriate validated method or the creation of a new chart tailored to the requirements of their study. Feminine hygiene technology will continue to advance, and the market should be constantly monitored for product updates. New devices for electronic data capture will also be developed and may become the method of choice for recording patient results. Pictorial charts must keep pace with these changes and be revalidated accordingly if they are to remain the chosen tool to assess MBL in clinical research. With these caveats in mind, we suggest that the PBAC can be a useful tool to determine MBL under defined and controlled study conditions.

National Institute for Health and Care Excellence (NICE). Heavy menstrual bleeding: assessment and management. NICE guideline [NG88]. 2018, updated November 2018. https://www.nice.org.uk/guidance/ng88/chapter/Recommendations Accessed 6 June 2018.

Rahi PM, Mojgan, Mohammad-Alizadeh S, Javadzadeh Y. Effects of mefenamic acid versus quince on menorrhagia and quality of life: a randomized controlled trial. Iran Red Crescent Med J. 2018. https://doi.org/10.5812/ircmj-16769.

Chi C, Bapir M, Lee CA, Kadir RA. Puerperal loss (lochia) in women with or without inherited bleeding disorders. Am J Obstet Gynecol. 2010;203:56.ep1–5.

Seitz C, Bumbuliene Z, Costa AR, Heikinheimo O, Heweker A, Hudecek R, et al. Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids. Contemp Clin Trials. 2017;55:56–62.

Tampon designs have progressively improved to limit leakage of menstrual fluid. Because they are worn internally, tampons are categorized by the US FDA as Class II Medical Devices. The maximum fluid retention weight for each absorbency category is strictly controlled, and all brands at the same rating must have the same maximum absorption capacity. Although most brands of unused tampons look essentially similar, the shape and dimensions of a worn item can vary considerably depending on the expansion and absorbency properties of the materials used. Figure 5 shows examples of tampon shapes after the addition of fluid. Using tampons during a menstrual period is less likely to result in extraneous fluid loss. Some women prefer the option and added sense of security of wearing a tampon and towel together because it gives greater personal choice; furthermore, this may potentially lead to an increased likelihood of patient recruitment and compliance in clinical studies [5, 86]. However, some women do not like tampons, particularly at times of heavy flow, and they are not included in all PBACs. If tampon icons are featured, they should represent the staining patterns produced by that particular brand.

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Warner PE, Critchley HO, Lumsden MA, Campbell-Brown M, Douglas A, Murray GD. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obstet Gynecol. 2004;190:1216–23.

Vercellini P, Oldani S, De Giorgi O, Milesi M, Merlo D, Crosignani PG. Endometrial ablation with a vaporizing electrode. II. Clinical outcome of a pilot study. Acta Obstet Gynecol Scand. 1998;77:688–93.

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Dashtinejad E, Abedi P, Afshari P. Comparison of the effect of breast pump stimulation and oxytocin administration on the length of the third stage of labor, postpartum hemorrhage, and anemia: a randomized controlled trial. BMC Pregnancy Childbirth. 2018;18:293.

PBACs are best suited to the controlled and specific environment of clinical studies, where clinical outcome parameters are defined. The current lack of standardization precludes widespread use of the PBAC in primary care.

Several derivative PBACs were detected in our database search but, with the exception of those described above, objective confirmation of their validity was not reported. Most charts referenced the scoring system of Higham et al. and, to a lesser extent, Janssen et al., although several modifications were made. The brand(s) of sanitary products were stated for some PBACs [15, 41,42,43,44,45] but not for others [46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]. The icon illustrations were often different and/or the individual scores were altered, whether by error or by design [41, 43, 46,47,48,49, 51, 52, 55,56,57, 60,61,62,63, 66, 67].

Measured blood volumes compared with the menstrual pictogram scores. Known volumes of blood were applied to Kotex Regular maxi towels to produce similar stain sizes to those depicted by the highlighted icon scores on the menstrual pictogram of Wyatt et al., which was validated using an older, obsolete version of the same sanitary product. The difference in volume required and the effect of towel compression on stain area are shown. MP menstrual pictogram. Reprinted from a poster with permission from the author: Burnett PE et al., Comparison of Menstrual Pictogram Scoring to the Validated Alkaline Hematin Assay as Techniques for Measuring Blood Loss on Feminine Hygiene Products [75]

Burnett P, Chudnoff S, Turner L, Dadgar D. Comparison of menstrual pictogram scoring to the validated alkaline hematin assay as techniques for measuring blood loss on feminine hygiene products. http://kcasbio.com/wp-content/uploads/2014/02/AlkalineHematinComparisonPoster.pdf Accessed 13 Mar 2019.

van Dongen H, Janssen CA, Smeets MJ, Emanuel MH, Jansen FW. The clinical relevance of hysteroscopic polypectomy in premenopausal women with abnormal uterine bleeding. BJOG. 2009;116:1387–90.

Zakherah MS, Sayed GH, El-Nashar SA, Shaaban MM. Pictorial blood loss assessment chart in the evaluation of heavy menstrual bleeding: diagnostic accuracy compared to alkaline hematin. Gynecol Obstet Investig. 2011;71:281–4.

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HM Prison & Probation Service  (HMPPS) is keen to encourage alternative working arrangements. Work life balance provides greater opportunities for staff to work more flexibly wherever managers and establishments can accommodate requests to do so. HMPPS offers flexible working subject to completion of a satisfactory probationary period and NVQ

Bolton-Maggs P. Women’s issues in bleeding disorders: menorrhagia, pregnancy and delivery. Montreal: The World Federation of Hemophilia. www.haemophilia.org.au/conferences/2009-conference/abstracts-and-presentations. Accessed 11 Jan 2019

Falahat F, Ayatiafin S, Jarahi L, Mokaberinejad R, Rakhshandeh H, Feyzabadi Z, et al. Efficacy of a herbal formulation based on Foeniculum Vulgare in oligo/amenorrhea: a randomized clinical trial. Curr Drug Discov Technol. 2018. https://doi.org/10.2174/1570163815666181029120512.

Magnay JL, Schonicke G, Nevatte TM, O'Brien S, Junge W. Validation of a rapid alkaline hematin technique to measure menstrual blood loss on feminine towels containing superabsorbent polymers. Fertil Steril. 2011;96:394–8.

Han JY, Lee EJ, Jee BC, Kim SH. Menstrual characteristics in Korean women with endometriosis: a pilot study. Obstet Gynecol Sci. 2018;61:142–6.

Hacioglu S, Karabulut A, Sari I, Keskin A. Haemostatic disorders in reproductive age women with menorrhagia and effects on quality of life. J Obstet Gynaecol. 2016;36:1041–5.

Johannes CB, Crawford SL, Woods J, Goldstein RB, Tran D, Mehrotra S, et al. An electronic menstrual cycle calendar: comparison of data quality with a paper version. Menopause. 2000;7:200–8.

Kiseli M, Kayikcioglu F, Evliyaoglu O, Haberal A. Comparison of therapeutic efficacies of norethisterone, tranexamic acid and levonorgestrel-releasing intrauterine system for the treatment of heavy menstrual bleeding: a randomized controlled study. Gynecol Obstet Investig. 2016;81:447–53.

Repros Therapeutics Phase IIb primary endpoint pictorial blood assessment chart https://www.sec.gov/Archives/edgar/data/897075/000114420412061769/v328279_ex99-1.htm Accessed 12 Jan 2019.

At a practical level, the chart would require at least one menstrual cycle to complete. Results would not normally be available during a first consultation, unless a PBAC had been completed beforehand by prior arrangement with the healthcare center. A dedicated women’s clinic might suit this purpose, in which a nurse practitioner could train patients to use a validated PBAC, distribute the required sanitary protection and address any queries or anxieties [119]. Some women may be discouraged because of the inevitable delay in diagnosis, the rigorous attention to detail required when scoring MBL, the stipulation to change sanitary wear frequently to avoid leakage (which might not always be possible) or the need to use specified and possibly unfamiliar sanitary products. A diagnostic ‘primary care’ PBAC that has been validated for a range of popular sanitary products, particularly those designed for heavy menstrual flow, together with appropriate instruction and support may help to alleviate these concerns. Also, the widespread availability and popularity of smartphones opens the possibility of developing ePBACs that would be acceptable to patients. However, this area has yet to be explored.

Woeller KE, Hochwalt AE. Safety assessment of sanitary pads with a polymeric foam absorbent core. Regul Toxicol Pharmacol. 2015;73:419–24.

Extraneous blood loss is the passage of menstrual fluid that is not captured by a sanitary product. It can occur at times of excessive MBL, when the absorption capacity of the sanitary item is exceeded, or when there is nothing to absorb the menstrual flow, e.g. while bathing without a tampon inserted in the vagina. Opinions differ as to whether extraneous loss significantly contributes to the overall volume of menstrual discharge [7, 31, 32, 34], although it may be an important factor in influencing how women perceive their MBL. Noncaptured extraneous MBL is difficult to quantitate accurately because it cannot be measured by the AH technique. Most validated PBACs do not include flooding episodes (Table 4), nor do many derivative charts [47, 49, 51, 52, 56, 87]. Some require women to simply record the number of flooding events [41, 48] or to allocate 5 points for each flooding episode, regardless of severity [88, 89]. The Wyatt pictogram judges extraneous loss by scoring the graded decrease in visibility of a coin placed in the base of a toilet pan when incremental volumes of blood are added [34]. However, in the everyday setting, this measurement would depend on the dimensions of the toilet receptacle, the volume of diluting water and the availability of (nonretrievable) coins to perform the test.

The appropriate time point to test efficacy will need to be considered, subject to the type and purpose of therapy. Medical treatments designed to rapidly reduce MBL tend to have short follow-up times of between 1 month and 12 months [44, 110,111,112,113], whereas surgical interventions, such the levonorgestrel intrauterine system and endometrial ablation, are designed for long-term reduction of MBL. Monitoring of menstrual loss has been reported for up to 5 years after surgery at various time intervals, depending on the study [59, 106, 107, 114]. The post-treatment time point(s) for MBL measurement should be clearly defined in the trial design.

Clinical trials often require a quantitative change in MBL as evidence of treatment efficacy for HMB. If a PBAC is used for this purpose, a decision must be made whether to use a validated method or to develop a new device. If the plan is to use an existing chart, attention should be focused on those certified for modern products [5, 35]. Authors should try to identify the study design that most closely matches their own setting. The prevalence of HMB in the reference PBAC report can be used as a guide if that of the intended study population is known [84].

Prashanthi GC, Popuri PK, Valluri P. Efficacy of tranexamic acid in the management of menorrhagia. Acta Biomed Sci. 2016;3:116–20.

Knol HM, Mulder AB, Bogchelman DH, Kluin-Nelemans HC, van der Zee AG, Meijer K. The prevalence of underlying bleeding disorders in patients with heavy menstrual bleeding with and without gynecologic abnormalities. Am J Obstet Gynecol. 2013;209:202.e1–7.

Whiting PF, Weswood ME, Rutjes AW, Reitsma JB, Bossuyt PN, Kleijnen J. Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies. BMC Med Res Methodol. 2006;6:9.

All diagnostic methods have limitations, particularly those with a subjective element. Each PBAC image is allocated a specific score, but patients may assign a range of blood volumes to the same icon category. The choice of icon may be influenced by whether a woman perceives her menstrual loss to be light, normal or excessive. A visual rating system is not as accurate as the AH method, which provides a definitive blood volume and does not rely on individual perception of MBL or errors in selecting or recording the correct icon. Pictorial charts may overestimate low volumes of MBL because whole blood represents a smaller proportion of the visible stain area than at normal and high volumes (Fig. 3). Conversely, the score assigned to the highest icon category can markedly underestimate MBL because of a ceiling effect as a sanitary item becomes fully saturated.

Deal LS, Williams VS, Fehnel SE. Development of an electronic daily uterine fibroid symptom diary. Patient. 2011;4:31–44.

Heavy menstrual bleeding (HMB) is a common gynecological condition that adversely affects quality of life and work productivity. Approximately 10–35% of women report heavy menstrual periods at some stage during their reproductive years, with 5% consulting a medical practitioner for investigation of HMB [1]. In research, HMB is defined as a measured menstrual blood loss (MBL) of > 80 mL per cycle, but studies have repeatedly shown that at least 40% of women seeking medical attention for heavy periods lose less than this volume [2,3,4,5]. In clinical practice, the decision to treat is usually based on a woman’s self-reported symptoms and the effect of these symptoms on quality of life rather than any objective measurement, which concurs with current guidelines for management of HMB [6]. However, self-perception of menstrual loss is unreliable [4, 7].

· nationals of the EU, Switzerland, Norway, Iceland or Liechtenstein and family members of those nationalities who have made a valid application for settled or pre-settled status under the European Union Settlement Scheme (EUSS)

Laberge P, Garza-Leal J, Fortin C, Sabbah R, Fulop T, Pasztor N, et al. One-year follow-up results of a multicenter, single-arm, objective performance criteria-controlled international clinical study of the safety and efficacy of the Minerva endometrial ablation system. J Minim Invasive Gynecol. 2015;22:1169–77.

Apart from the diversity in diagnostic accuracy – a fact highlighted by validated PBACs – there is a lack of standardization in measuring post-treatment outcomes. The aim of therapy is to improve a patient’s well-being to an acceptable level, but the relationship between quality of life and a clinically meaningful decrease in MBL remains unresolved. With a single exception, pictorial charts have not been validated as a tool to test the effectiveness of therapy [36], and researchers have had to define their own criteria for treatment success. Some have stipulated a decrease in PBAC score to below the chosen HMB cut-off value [95] or by a certain number of points from the baseline measurement of MBL, e.g. 50 points [15, 96,97,98]. Others have advocated a percentage reduction in score; values of 20–50% have been reported [36, 58, 59, 63, 99,100,101,102,103,104,105]. If the treatment goal is amenorrhea (PBAC score < 2), the endpoint is clearly defined [54, 106,107,108,109]. The aim of several reports is just to detect a significant difference in MBL reduction between different treatments for HMB.

The blood volume of menstrual clots is difficult to quantify. Clots can be quite gelatinous and contain varying amounts of endometrial tissue and vaginal secretions. The blood component cannot be verified by AH unless captured on sanitary wear and isolated for analysis. Many PBACs omit this element altogether [5, 33, 36, 47, 51, 56, 57, 87]. Some charts compare clot sizes to specific coinage [29, 31, 88] or to full-sized icons of stated diameters [54] (Fig. 6). The Wyatt pictogram depicts clots as a series of irregular shapes, but there is no associated size comparator [37]. Other PBACs use a subjective description of size – e.g. ‘small’ or ‘big/large’ – or just a ‘yes/no’ response, without reference to any measurable standard [32, 48, 49, 55]. Menstrual clot scoring is theoretically suitable for electronic versions of the PBAC if images are presented as actual-sized screenshots.

Nevatte TM, Borlase D, Magnay JL, O'Brien S. Evaluation of the menstrual pictogram and detergent based alkaline haematin method for use with ultra slim sanitary towels. BJOG. 2008;115:191.

Country Report. Sanitary protection in the US. London: Euromonitor International; 2013. Available at http://www.euromonitor.com/sanitary-protection-in-the-us/report. Accessed 10 July 2013

Wyatt KM, Dimmock PW, Hayes-Gill B, Crowe J, O'Brien PM. Menstrual symptometrics: a simple computer-aided method to quantify menstrual cycle disorders. Fertil Steril. 2002;78:96–101.

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Larsen L, Coyne K, Chwalisz K. Validation of the menstrual pictogram in women with leiomyomata associated with heavy menstrual bleeding. Reprod Sci. 2013;20:680–7.

Ashraf MN, Habib-Ur-Rehman A, Shehzad Z, AlSharari SD, Murtaza G. Clinical efficacy of levonorgestrel and norethisterone for the treatment of chronic abnormal uterine bleeding. J Pak Med Assoc. 2017;67:1331–8.

Shapley M, Redman CWE. Assessment of menstrual blood loss using a pictorial chart and endometrial sampling within the community. J Obstet Gynaecol. 1995;15:123–4.

MacEachern K, Kaur H, Toukh M, Mumal I, Hamilton A, Scovil S, et al. Comprehensive evaluation of hemostasis in normal women: impact on the diagnosis of mild bleeding disorders. Clin Appl Thromb Hemost. 2015;21:72–81.

The format of a validated PBAC should not vary during use because it may change a patient’s perception of her MBL and, thus, her score. Because towels and tampons often have distinctive shapes and sizes, icon images need to represent the feminine items used [5, 86]. Successive icons must display clear differences in appearance to avoid indecision or mis-scoring. If a paper-based PBAC is chosen, the chart and menstrual diary should easily fit into a typical daytime-sized handbag and have a neutral, discrete cover. It must have a robust construction to prevent disintegration and allow sufficient room for the number of soiled feminine items to be recorded each day [86]. Prospective daily recording is critical for data collection involving a series of recurrent similar events such as MBL, in which the accuracy of retrospective recall tends to be low [90].

To gain maximum patient compliance, use of the PBAC must be as straightforward as possible. At an early stage, patients’ views should be sought about the method and how it may be improved, and the level of compliance should be tested [86, 92]. Women should be supplied with sufficient feminine materials, based on their expected MBL, and carefully instructed on how to score their soiled items. This includes interpretation of nonstandard or fragmented staining patterns. The importance of prospective recording must be emphasized, and the contact details of a liaison nurse should be available in case of any concerns.

Hald K, Lieng M. Assessment of periodic blood loss: interindividual and intraindividual variations of pictorial blood loss assessment chart registrations. J Minim Invasive Gynecol. 2014;21:662–8.

van Eijkeren MA, Scholten PC, Christiaens GC, Alsbach GP, Haspels AA. The alkaline hematin method for measuring menstrual blood loss--a modification and its clinical use in menorrhagia. Eur J Obstet Gynecol Reprod Biol. 1986;22:345–51.

Herman MC, Mak N, Geomini PM, Winkens B, Mol BW, Bongers MY. Is the pictorial blood loss assessment chart (PBAC) score associated with treatment outcome after endometrial ablation for heavy menstrual bleeding? A cohort study. BJOG. 2017;124:277–82.

Ergun B, Bastu E, Ozsurmeli M, Celik C. Tranexamic acid: a potential adjunct to resectoscopic endometrial ablation. Int Surg. 2012;97:310–4.

Huq FY, Al-Haderi M, Kadir RA. The outcome of endometrial ablation in women with inherited bleeding disorders. Haemophilia. 2012;18:413–20.

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Goshtasebi A, Moukhah S, Gandevani SB. Treatment of heavy menstrual bleeding of endometrial origin: randomized controlled trial of medroxyprogesterone acetate and tranexamic acid. Arch Gynecol Obstet. 2013;288:1055–60.

Liu M, Cheng Z, Dai H, Qu X, Kang L. Long-term efficacy and quality of life associated with laparoscopic bilateral uterine artery occlusion plus partial resection of symptomatic adenomyosis. Eur J Obstet Gynecol Reprod Biol. 2014;176:20–4.

Median percentage blood fraction of menstrual fluid versus icon category of menstrual pictogram (SAP-c version). Second-order polynomial curve fit of median percentage blood fraction of menstrual discharge, with respect to icon category of the menstrual pictogram (SAP-c version); n = 3257 Always Ultra sanitary towels. PBAC pictorial blood loss assessment chart, SAP-c superabsorbent-polymer-containing. Reprinted from Fertility and Sterility, 101, Magnay JL et al., Validation of a new menstrual pictogram (superabsorbent polymer-c version) for use with ultraslim towels that contain superabsorbent polymers pp515–22, Copyright 2014, with permission from Elsevier [5].

Puri K, Famuyide AO, Erwin PJ, Stewart EA, Laughlin-Tommaso SK. Submucosal fibroids and the relation to heavy menstrual bleeding and anemia. Am J Obstet Gynecol. 2014;210:38.e1–7.

Magnay, J.L., O’Brien, S., Gerlinger, C. et al. Pictorial methods to assess heavy menstrual bleeding in research and clinical practice: a systematic literature review. BMC Women's Health 20, 24 (2020). https://doi.org/10.1186/s12905-020-0887-y

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All included components of a PBAC should be assessed. The value assigned to individual towel and tampon icons should be verified against AH for every selected absorbency category. Allocating blood volumes to each icon (as opposed to an empirical value) allows direct assessment of MBL, as in the menstrual pictogram. Whichever scoring system is used, it must be sufficiently sensitive to detect what are considered to be clinically relevant differences in MBL at the appropriate time point following treatment for HMB. An important issue to consider is the increase in stain area when a feminine towel or tampon is subjected to mechanical load [75]. Compression forces exerted by the wearer may ultimately affect icon selection. Choosing products that show minimal stain spread under pressure would limit this confounding element [5, 86]. Other factors that can affect visible stain area are the rate and composition of menstrual flow, individual anatomy, physical activity and posture. It is difficult to control for these variables.

Vasilenko P, Kraicer PF, Kaplan R, de Masi A, Freed N. A new and simple method of measuring menstrual blood loss. J Reprod Med. 1988;33:293–7.

Gannon MJ, Day P, Hammadieh N, Johnson N. A new method for measuring menstrual blood loss and its use in screening women before endometrial ablation. Br J Obstet Gynaecol. 1996;103:1029–33.

Mohebbi-Kian E, Mohammad-Alizadeh-Charandabi S, Bekhradi R. Efficacy of fennel and combined oral contraceptive on depot medroxyprogesterone acetate-induced amenorrhea: a randomized placebo-controlled trial. Contraception. 2014;90:440–6.

Kilic C, Sarper N, Zengin E, Aylan Gelen S. Screening bleeding disorders in adolescents and young women with menorrhagia. Turk J Haematol. 2013;30:168–76.

The role of PBACs in primary care is currently unclear. The usual procedure to assess MBL combines a woman’s self-perception of her menstrual flow (in terms of light, normal or heavy) with hemoglobin level and/or menstrual markers, such as length of period, number of used sanitary products, number of days of ‘heavy’ bleeding, number of flooding episodes and size of clots passed. Together with quality-of-life issues, this subjective approach is often the only trigger for medical and surgical interventions, although it is unreliable [2, 31, 76].

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A literature review was conducted using Embase and MEDLINE databases. The review identified reports of women with self-perceived or actual heavy menstrual bleeding (HMB), bleeding disorders, abnormal uterine bleeding, leiomyomata (uterine fibroids) or endometriosis, and women undergoing treatment for HMB, as well as those with normal menstrual periods. Data were reviewed from studies that focused on the development and validation of PBACs and from those that used derivative noncertified charts to assess HMB.

Leeflang MM, Rutjes AW, Reitsma JB, Hooft L, Bossuyt PM. Variation of a test’s sensitivity and specificity with disease prevalence. CMAJ. 2013;185:E537–44.

Magnay JL, Nevatte TM, Dhingra V, O'Brien S. Menstrual blood loss measurement: validation of the alkaline hematin technique for feminine hygiene products containing superabsorbent polymers. Fertil Steril. 2010;94:2742–6.

Agarwal N, Gupta M, Kriplani A, Bhatla N, Singh N. Comparison of combined hormonal vaginal ring with ultralow-dose combined oral contraceptive pills in the management of heavy menstrual bleeding: a pilot study. J Obstet Gynaecol. 2016;36:71–5.

Lee CA, Kadir RA, Kouides PA. Pictorial blood loss assessment chart. Inherited bleeding disorders in women. Hoboken: Blackwell Publishing Ltd; 2009. Appendix ii 186–7

Canadian Hemophilia Society. Menstrual assessent chart. https://www.hemophilia.ca/files/Menstrual%20Assessment%20Chart.pdf Accessed 11 Jan 2019.

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Hoaglin DC, Filonenko A, Glickman ME, Wasiak R, Gidwani R. Use of mixed-treatment-comparison methods in estimating efficacy of treatments for heavy menstrual bleeding. Eur J Med Res. 2013;18:17.

Mawet M, Nollevaux F, Nizet D, Wijzen F, Gordenne V, Tasev N, et al. Impact of a new levonorgestrel intrauterine system, Levosert((R)), on heavy menstrual bleeding: results of a one-year randomised controlled trial. Eur J Contracept Reprod Health Care. 2014;19:169–79.

Ahuja SP, Hertweck SP. Overview of bleeding disorders in adolescent females with menorrhagia. J Pediatr Adolesc Gynecol. 2010;23:S15–21.

Fraser IS, McCarron G, Markham R, Resta T. Blood and total fluid content of menstrual discharge. Obstet Gynecol. 1985;65:194–8.

Gupta S, Lemanczyk MA, Christopherson PA, Yan K, Hoffmann RG, Lund MR, et al. Cross sectional study to evaluate the utility of screening tools to identify low von Willebrand factor levels in women with menorrhagia (ZPMCB-VWD). Blood. 2010;116:3839.

Lin X, Gao ES, Li D, Zhang M, Dou LX, Yuan W. Preventive treatment of intrauterine device-induced menstrual blood loss with tranexamic acid in Chinese women. Acta Obstet Gynecol Scand. 2007;86:1126–9.

You must ensure that any evidence submitted as part of your application, including your CV, statement of suitability and behaviour examples, are truthful and factually accurate. Please note that plagiarism can include presenting the ideas and experiences of others, or generated by artificial intelligence, as your own.

Examples of PBAC clot scoring icons. Actual-size diameters shown (cm) [29, 37, 52, 54, 88]. PBAC pictorial blood loss assessment chart. Clot scoring adapted from Obstetrician & Gynaecologist, 6, Warrilow G et al., Quantification of menstrual blood loss, pp88–92, Copyright 2004 Royal College of Obstetricians and Gynaecologists, with permission from John Wiley and Sons

This PBAC was reassessed in 1994, although women were allowed to use their usual sanitary materials rather than those initially validated. With a specificity of 52%, it detected more false positives than the Higham study [30]. A year later, a modified pictorial chart was certified for use with specific feminine products. The scoring system was identical to the Higham PBAC, but the icons looked different (Fig. 2b). Based on receiver operating characteristic analysis, a cut-off point of 185 showed the greatest positive and negative predictive values for HMB, and it was concluded that a score of > 185, rather than > 100, should be used as a diagnostic threshold [31]. In 1999, adolescent Nigerian girls tested a novel pictorial chart with four towel icons (Fig. 2c). The sanitary products were not identified. Maximum sensitivity and specificity were achieved at a cut-off score of only 50, which was attributed to the fact that all the study population had normal MBL [32]. In 2000, the validity of the PBAC was challenged when Reid et al. tried to reproduce findings from the Higham pictorial chart on a population of women with self-reported HMB. Based on a specificity of 7.5% and a low correlation (r = 0.47) between PBAC score and AH, it was judged to be an inappropriate method to measure MBL [33].

The PBAC must be tested by a spectrum of women with light, normal and heavy MBL to assess not only its validity as a diagnostic tool for HMB but also its ability to estimate normal and low menstrual volumes. Many women who complain of HMB actually have normal periods, and those with excessive blood loss often experience dramatic reductions in MBL after treatment. The scores should be reproducible and yield the same results in repeated applications [86].

The nine validation studies are discussed below in chronological order of publication, demonstrating the processes required to develop and to certify a pictorial method to measure MBL.

In 2001, a new version of the PBAC was introduced by Wyatt et al. The menstrual pictogram depicted five icons representing blood loss on towels and four icons for tampons. The method was validated using simulated menstrual fluid (blood/saline, 1:1 ratio) to represent the physiological setting, in which the visible stain typically comprises about 50% blood (J.L. Magnay and K.M. Wyatt, personal communication). Scores for blood clots and extraneous loss were included. Crucially, all scores were quoted as blood volume with a cut-off limit of 80 mL, which made it directly comparable to the AH technique. The pictogram was validated using specified towel and tampon brands with various absorbency ratings (Fig. 2d) [34].

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Khadige A, Keshavarz Z, Mojab F, Majd HA. The effect of Teucrium polium on the duration of menstrual bleeding: a triple-blind placebo-controlled clinical trial. Electron Physician. 2017;9:5233–6.

Since these early validation studies, towel and tampon manufacturers have responded to market demand for more comfortable, discrete feminine products with enhanced fluid absorbency. Sanitary products used in the early PBACs became obsolete, and ultra-slim towels containing superabsorbent polymers rapidly gained popularity. In 2011, an updated version of the Higham chart was validated for Always Ultra towels (Proctor & Gamble, Cincinnati, OH, USA), the most popular brand of ultra-slim towel in the USA and UK [38, 39]. Tampons, clots and episodes of flooding were not evaluated so, to minimize extraneous loss, women were asked to use double towels during episodes of HMB. Maximum sensitivity and specificity were achieved at a cut-off score of 150 [35]. Two years later, Larsen et al. revalidated the menstrual pictogram after obtaining identical sanitary wear to that used in the original chart by Wyatt et al. (J.L. Magnay and L. Larsen, personal communication). At a threshold of 80 mL, the method gave a sensitivity of 96% and a specificity of 92% in dichotomizing response to medical treatment in terms of a ≥ 50% or < 50% decrease in MBL. This was the first time a pictorial chart had been endorsed for other than diagnostic purposes; namely, the MBL assessment of women with uterine fibroids treated with an investigational drug [36]. However, the validation was done with an obsolete version of feminine items and cannot be applied to other studies. In 2014, a new menstrual pictogram (SAP-c version) was validated with simulated menstrual fluid for use with Always Ultra towels and a choice of three absorbencies (Fig. 2e). Correction factors were applied to the provisional icon scores to account for the progressive increase in blood fraction with menstrual volume, as demonstrated in Fig. 3 [5, 26, 40]. The cut-off value for HMB was 80 mL.

Examples of menstrual tampon shapes after addition of fluid. Anti-leak features of each tampon type are shown. When wet, o.b. ProComfort tampons swell radially to form a barrel shape, Tampax Cardboard tampons enlarge axially with minimal radial expansion and Tampax Pearl tampons expand to produce a winged profile. o.b. ProComfort tampons, Edgewell Personal Care, St Louis, MO, USA; Tampax tampons, Proctor & Gamble, Cincinnati, OH, USA

The Civil Service embraces diversity and promotes equal opportunities. As a Disability Confident employer, MoJ are committed to providing everyone with the opportunity to demonstrate their skills, talent and abilities, by making adjustments throughout all elements of the recruitment process and in the workplace. MoJ are able to offer an interview to disabled candidates who meet the minimum selection criteria, except in a limited number of campaigns.

If an electronic design is preferred (e.g. a dedicated eDiary, smartphone application or website), a paper version may still be needed in situations in which telephone or Internet reception is unavailable, the equipment has insufficient battery charge, or it has been lost or damaged. Electronic recording of MBL is not a new concept. In 2002, a menstrual symptometrics device for use by patients incorporated a menstrual pictogram programmed into an Amstrad PDA600 PenPad [91]. It was validated for MBL measurement using the paper-based chart of Wyatt et al. as the reference standard [34]. Electronic data logging is generally preferred by patients and results in fewer missing data than a paper calendar and fewer transcription errors when results are transferred to a computer database [90]. A study showed that 80% of adolescents and young women preferred to use a smartphone application version of the PBAC over a paper-based chart, although the method was limited by mobile technology issues [92]. A second study developed an electronic PBAC (ePBAC) that could be completed using the Internet [93]. Neither chart had been validated against the AH method.

-You are entitled to 9 days (66 hours 36 minutes) in recognition of bank, public and privilege holidays. These hours are added to your annual leave allowance. There is a requirement to work some public and bank holidays subject to your shift pattern and the operational needs of the establishment

Many clinical trial protocols require treatment efficacy for HMB to be determined by quantitative changes in MBL before a license can be granted for a new drug or surgical procedure. The perceived gold-standard method to measure MBL is the alkaline hematin (AH) technique, which was established in 1964, with later modifications [3, 8,9,10,11,12]. It is an expensive procedure that requires specialized laboratory facilities. Patients must collect, store and then submit all their used feminine products for MBL analysis, which may not be acceptable or feasible for many women. Therefore, it is mainly confined to clinical trials and the research setting to confirm or refute HMB and to evaluate efficacy of medical or surgical treatments.

Corson SL, Brill AI, Brooks PG, Cooper JM, Indman PD, Liu JH, et al. One-year results of the vesta system for endometrial ablation. J Am Assoc Gynecol Laparosc. 2000;7:489–97.

Bırı A, Bozkurt N, Korucuoğlu Ü, Yilmaz E, Tiraş B, Güner H. Use of pictorial chart for managing menorrhagia among Turkish women. J Turk Ger Gynecol Assoc. 2008;9:35–7.

The job holder is expected to be competent in their area of work, any specific qualifications or training required will be detailed in the relevant job description.

Soper DE, Winkel C, Larsen L, Fries M, Lee R, Chwalisz K. Validation of the menstrual pictogram compared with the AH method to assess menstrual blood loss. Obstet Gynecol Sci. 2007;109(Suppl22S).

Donnez J, Hudecek R, Donnez O, Matule D, Arhendt HJ, Zatik J, et al. Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids. Fertil Steril. 2015;103:519–27.e3.

Endrikat J, Vilos G, Muysers C, Fortier M, Solomayer E, Lukkari-Lax E. The levonorgestrel-releasing intrauterine system provides a reliable, long-term treatment option for women with idiopathic menorrhagia. Arch Gynecol Obstet. 2012;285:117–21.

Nahidi F, Bagheri L, Jannesari S, Alavi MH. Relationship between delivery type and menstrual disorders: a case-control study. J Res Health Sci. 2011;11:83–90.

Extraneous MBL is common for women experiencing HMB and may be due to sudden flooding episodes, not changing sanitary products often enough or a combination of both. To limit this event, women should be encouraged to use tampons and towels concurrently, to ensure a fresh tampon is worn when showering/bathing or visiting the toilet and to change their feminine items as frequently as possible at times of heavy menstrual flow. If a woman does not wish to use tampons, she should choose towels with the highest absorbency rating and try to replace them before saturation occurs.

Qaraaty M, Kamali SH, Dabaghian FH, Zafarghandi N, Mokaberinejad R, Mobli M, et al. Effect of myrtle fruit syrup on abnormal uterine bleeding: a randomized double-blind, placebo-controlled pilot study. Daru. 2014;22:45.

This review was funded by Bayer AG, Berlin, Germany. Bayer AG did not contribute to the design of this review or to the collection of data, analysis and interpretation of the data or preparation of the manuscript beyond the individual contributions of the named authors who are employees of Bayer AG. Editorial support was provided by Oxford PharmaGenesis, Oxford, UK, and funded by Bayer AG, Berlin, Germany.

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The first PBAC was introduced in 1990 by Higham et al. and depicted three images (icons) that represented specific brands of feminine items soiled with increasing amounts of blood [29]. The icon scores were 1, 5 and 20 points for towels and 1, 5 and 10 points for tampons. A range of blood volumes produced visually similar stain sizes. Consequently, the score allocated to each icon was related, but not necessarily equal, to the applied blood volume in milliliters. The size of blood clots was compared with the diameter of UK coinage, and the number of flooding events was recorded, although there were no associated scores. Twenty-eight women of undisclosed menstrual status were monitored between one and 3 cycles each, giving 55 patient-assessed cycles in total. The PBAC scores ranged from 5 to 456 (median 121), whereas MBL measured by the AH technique ranged from 2 to 366 (median 74), giving a correlation coefficient (r) of 0.847. When used as a diagnostic test for HMB, a score of ≥100 gave a reported sensitivity and specificity of 86 and 89%, respectively. However, the PBAC progressively underestimated blood volume as menstrual loss increased, which demonstrated an important limitation of the method for women with HMB. The Higham PBAC is shown in Fig. 2a.

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Barrington JW, Bowen-Simpkins P. The levonorgestrel intrauterine system in the management of menorrhagia. Br J Obstet Gynaecol. 1997;104:614–6.

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Kriplani A, Srivastava A, Kulshrestha V, Kachhawa G, Agarwal N, Bhatla N, et al. Efficacy of ormeloxifene versus oral contraceptive in the management of abnormal uterine bleeding due to uterine leiomyoma. J Obstet Gynaecol Res. 2016;42:1744–52.

Magnay JL, Nevatte TM, Seitz C, O'Brien S. A new menstrual pictogram for use with feminine products that contain superabsorbent polymers. Fertil Steril. 2013;100:1715.e1–21.e4.

Kouides PA, Byams VR, Philipp CS, Stein SF, Heit JA, Lukes AS, et al. Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid. Br J Haematol. 2009;145:212–20.

Philipp CS, Faiz A, Heit JA, Kouides PA, Lukes A, Stein SF, et al. Evaluation of a screening tool for bleeding disorders in a US multisite cohort of women with menorrhagia. Am J Obstet Gynecol. 2011;204:209.e1–e2097.

Ragni MV, Jankowitz RC, Jaworski K, Merricks EP, Kloos MT, Nichols TC. Phase II prospective open-label trial of recombinant interleukin-11 in women with mild von Willebrand disease and refractory menorrhagia. Thromb Haemost. 2011;106:641–5.

Some studies have recommended the use of a PBAC in primary care to increase the diagnostic accuracy of HMB [35, 36, 46], possibly as an adjunct to clinical history and menstrual markers [65, 117, 118]. However, widespread application of this method is currently limited by a lack of expert consensus regarding the choice of pictorial chart, the diagnostic cut-off score for HMB and clear objective criteria in the assessment of post-treatment clinical outcome.

· individuals with limited leave to remain or indefinite leave to remain who were eligible to apply for EUSS on or before 31 December 2020

An alternative semiquantitative method uses a pictorial blood loss assessment chart (PBAC) to assess MBL. This simple, inexpensive tool comprises a visual scoring system that depicts a graded series of soiled tampons and/or towels. The patient can directly record the number of her used feminine items and the degree to which they are bloodstained. Since its inception in 1990, the PBAC has become increasingly accepted by regulatory bodies as a substitute for the AH technique [13] and is now the most widely used method in clinical studies to confirm HMB and to measure response to treatment [14, 15]. It has also been used to measure postpartum blood loss [16, 17], to screen women for investigation of hemostatic disorders for which HMB may be a key symptom (e.g. von Willebrand disease) [18,19,20] and to evaluate the cost-effectiveness of different therapies for HMB [21, 22]. Two studies have used a pictorial chart to measure an increase in MBL after treatment of amenorrhea, or infrequent menstrual periods, with agents containing herbal preparations [23, 24].

The "Making the Civil Service a Great Place to work for veterans" initiative includes a guaranteed interview scheme to those who meet the minimum criteria to provide eligible former members of the Armed Forces with opportunities to secure rewarding jobs. Allowing veterans to continue to serve their country, and to bring highly skilled individuals with a broad range of experience into the Civil Service in an environment, which recognises and values your previous service in the Armed Forces.For further details about the initiative and eligibility requirements visit : https://www.gov.uk/government/news/making-the-civil-service-a-great-place-to-work-for-veterans

Reid PC, Coker A, Coltart R. Assessment of menstrual blood loss using a pictorial chart: a validation study. BJOG. 2000;107:320–2.

European Medicines Agency. Summary of product characteristics. Esmya 5 mg tablets, INN-Ulipristal https://www.ema.europa.eu/documents/product-information/esmya-epar-product-information_en.pdf Accessed 8 Aug 2018.

Abu Hashim H, Alsherbini W, Bazeed M. Contraceptive vaginal ring treatment of heavy menstrual bleeding: a randomized controlled trial with norethisterone. Contraception. 2012;85:246–52.

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Cash C Jr, Garza-Leal J, Donovan A, Guidry C, Romanowski C, Patel B. Clinical evaluation of long-term safety and effectiveness of a third-generation thermal uterine balloon therapy system for heavy menstrual bleeding. J Minim Invasive Gynecol. 2012;19:469–76.

Treetampinich C, Suwannarurk K, Chanthasenanont A, Fongsupa S, Tamrongterakul T, Rattanachaiyanont M. Blood absorption capacity of various sanitary pads available in Thailand. Siriraj. Med J. 2017;59:303–6.

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Jacobson AE, Vesely SK, Haamid F, Christian-Rancy M, O'Brien SH. Mobile application vs paper pictorial blood assessment chart to track menses in young women: a randomized cross-over design. J Pediatr Adolesc Gynecol. 2018;31:84–8.

Lopes JE Jr, Sherer E. Managing menorrhagia. Evaluating and treating heavy menstrual bleeding. Adv NPs PAs. 2010;1:21–4 quiz 5.

We encourage applications from people from all backgrounds and aim to have a workforce that represents the wider society that we serve. We pride ourselves on being an employer of choice. We champion diversity, inclusion and wellbeing and aim to create a workplace where everyone feels valued and a sense of belonging. To find out more about how we do this visit: https://www.gov.uk/government/organisations/ministry-of-justice/about/equality-and-diversity.

Mun S, Uysal A. The effects of hysteroscopic submucosal myoma resection on number of sanitary pads. J Clin Anal Med. 2015;6:75–8.

Gorgen H, Api M, Akca A, Cetin A. Use of the Levonorgestrel-IUS in the treatment of menorrhagia: assessment of quality of life in Turkish users. Arch Gynecol Obstet. 2009;279:835–40.

From Embase and MEDLINE, 837 records were retrieved on February 11, 2018, and a further 34 were retrieved on November 2, 2018. After removal of duplicates and articles that did not validate a PBAC against the AH method, nine validation studies were identified. Reported quality parameters of the nine studies were generally satisfactory, and no studies were considered to have a very high risk of bias (Additional file 2). However, with one exception (Magnay et al. 2014 [5]), it was unclear whether PBAC test scores were interpreted without knowledge of AH results, and vice versa (test review bias and reference review bias, respectively). Also, it was unclear whether clinical information would normally be available when the index test is used in practice (clinical review bias). Statistical data for the individual studies are summarized in Table 1. The pooled population from these reports comprised 1347 women with a wide spectrum of MBL levels. This corresponded to 1821 menstrual cycles for which AH data and self-assessed PBAC scores were available. Across these nine studies, the diagnostic threshold score ranged from 50 to 185. The sensitivity was 58–97%, the specificity was 7.5–95.5%, the LR+ was 1.1–13.8 and the LR− was 0.14–0.56. The DOR was in the range 2.6–52.4, with the menstrual pictogram (superabsorbent-polymer-containing [SAP-c] version) giving the highest value [5]. It is generally accepted that the greater the DOR, the better the discriminatory test performance. However, measures of diagnostic accuracy are not fixed indicators of test performance. The diagnostic accuracy of one study may not apply to other patient groups and settings – a fact that is often overlooked. It was not feasible to pool data for meta-analysis because of the wide diversity in patient demographics, HMB prevalence, sanitary products, study procedures, cut-off scores and data analysis.

In numerous cases, a validated PBAC was referenced, but the cut-off threshold was adjusted for no obvious reason [46, 55,56,57, 59, 64, 65, 68,69,70,71,72]. Two reports directly compared the Higham and Janssen scoring systems (HMB > 100 and > 185, respectively) in the same study [73, 74]. In some instances, contemporary towels and tampons were deliberately substituted for their validated obsolete counterparts [16, 42, 75], but the cut-off score was not re-established. For a given volume, the visible stained area on modern sanitary materials is less than on older products [75] and can vary greatly between different brand formulations and absorbency ratings [41, 75,76,77,78]. Four studies directly converted PBAC score to MBL volume [17, 72, 79, 80]. However, this relationship is not linear because a range of blood volumes may be assigned to the same icon category. Three studies used a PBAC to simply assess the pattern of menstruation before and after treatment: the first to determine the length of menstrual period [81], the second to additionally record the number of towels used [82], and the third to measure the decrease in number of towels used at the time of heaviest menstrual loss [83]. None reported measured MBL. Table 2 lists some examples of modified, nonvalidated PBACs.

Fernandez H, Kobelt G, Gervaise A. Economic evaluation of three surgical interventions for menorrhagia. Hum Reprod. 2003;18:583–7.

Recommendations for the validation and use of PBACs were based on a systematic review of the electronic databases Embase and MEDLINE in February 2018, and again in November 2018. The review protocol was registered at PROSPERO (https://www.crd.york.ac.uk/PROSPERO) in March 2016: record number CRD42016030083. The search terms and selection process are shown in Additional file 1 and in Fig. 1. Articles were independently screened by two of the authors (J.L.M. and C.S.) for inclusion criteria. To be included in the literature review, articles were assessed for eligibility in terms of patients, outcomes and study design. The initial objective was to detect reports in which a pictorial chart had been used to measure MBL. The search was then specifically focused on studies that validated a PBAC against the AH method. The primary outcome was defined as the diagnostic accuracy of pictorial charts to determine HMB compared with objective quantitation; a volume of > 80 mL measured by the AH technique was considered to be diagnostic of excessive MBL [7]. The relevant data were extracted from text, tables or figures within the reports, and the quality of each study was evaluated using the QUADAS tool for the quality assessment of diagnostic accuracy studies; see Additional file 2 (Whiting et al. 2006 [27]). The diagnostic accuracy of each validated chart was calculated in terms of sensitivity, specificity, positive and negative likelihood ratios (LR + and LR−, respectively), and diagnostic odds ratio (DOR) [28]. In this setting, diagnostic accuracy was defined as the ability of a PBAC to discriminate between HMB and normal blood loss. Results that exceeded the stated cut-off threshold were classed as positive (HMB confirmed), and those below the threshold were classed as negative (HMB excluded).

The MoJ offers Hybrid Working arrangements where business need allows. This is an informal, non-contractual form of flexible working that blends working from your base location, different MoJ sites and / or from home (please be aware that this role can only be worked in the UK and not overseas). Some roles will not be suitable for Hybrid Working. Similarly, Hybrid Working will not suit everyone’s circumstances. Arrangements will be discussed and agreed with the successful candidate(s) and subject to regular review.

Rees MCP. Role of menstrual blood loss measurements in management of complaints of excessive menstrual bleeding. BJOG. 1991;98:327–8.

Arora D, Chawla J, Kochar SPS, Sharma JC. A randomized control trial to assess efficacy of mifepristone in medical management of uterine fibroid. Med J Armed Forces India. 2017;73:267–73.

A potential drawback of using modern towels is the difficulty of visualizing the bloodstained area on the upper surface, because fluid is rapidly transferred to the interior region. The SAP-c menstrual pictogram overcomes this problem by scoring the stain on the underside of the towel, where it is clearly visible [5, 86]. Many stain profiles will not conform to the standardized PBAC icons [5, 94]. Stains may be fragmented or a completely different shape, which could potentially result in underestimation or overestimation of MBL, depending on personal perception of the soiled area.

Janssen CA, Scholten PC, Heintz AP. A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss. Obstet Gynecol. 1995;85:977–82.

Deeny M, Davis JA. Assessment of menstrual blood loss in women referred for endometrial ablation. Eur J Obstet Gynecol Reprod Biol. 1994;57:179–80.

Magnay JL, Nevatte TM, O'Brien S, Gerlinger C, Seitz C. Validation of a new menstrual pictogram (superabsorbent polymer-c version) for use with ultraslim towels that contain superabsorbent polymers. Fertil Steril. 2014;101:515–22.e5.

Success Profiles will enable a fairer and more inclusive method of recruitment by enabling us to assess the range of experiences, abilities, strengths, behaviours and technical/professional skills required for different roles. This flexible approach to recruitment focuses more on finding the right candidate for the specific role. To find out more about Success Profiles to support your application please click here for further guidance.

Warner P, Weir CJ, Hansen CH, Douglas A, Madhra M, Hillier SG, et al. Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM). BMJ Open. 2015;5.

Higham JM, O'Brien PM, Shaw RW. Assessment of menstrual blood loss using a pictorial chart. Br J Obstet Gynaecol. 1990;97:734–9.

An ability to fulfil all spoken aspects of the role with confidence through the medium of English or (where specified in Wales) Welsh

Gopimohan R, Chandran A, Jacob J, Bhaskar S, Aravindhakshan R, Aprem AS. A clinical study assessing the efficacy of a new variant of the levonorgestrel intrauterine system for abnormal uterine bleeding. Int J Gynaecol Obstet. 2015;129:114–7.

Bongers M, Brolmann H, Gupta J, Garza-Leal JG, Toub D. Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate(R) system: three- and six-month endpoint results from the FAST-EU study. Gynecol Surg. 2015;12:61–70.

Fraser IS, Warner P, Marantos PA. Estimating menstrual blood loss in women with normal and excessive menstrual fluid volume. Obstet Gynecol. 2001;98:806–14.

For nationally advertised roles, the successful candidate(s) will be appointed to a MoJ office location, which may include their nearest Justice Collaboration Centre or Justice Satellite Office. This will be discussed and agreed on the completion of pre-employment checks.

Examples of validated PBACs reported in the literature. PBAC pictorial blood loss assessment chart. a. The PBAC presented by Higham et al. reproduced from British Journal of Obstetrics and Gynaecology, 97, Higham JM et al. Assessment of menstrual blood loss using a pictorial chart, pp734–9, Copyright 2005, with permission from John Wiley and Sons [29]. b. The chart presented by Janssen et al. Adapted from Obstetrics & Gynecology, 85, Janssen CA et al. A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss, pp977–82, Copyright 1995, with permission from Elsevier [31]. c. The pictorial chart presented by Barr et al. Reproduced from International Journal of Gynecology & Obstetrics, 66, Barr F et al. A pictorial chart for managing common menstrual disorders in Nigerian adolescents, pp51–3, Copyright 1999, with permission from John Wiley and Sons [32]. d. The menstrual pictogram presented by Wyatt et al. Reprinted from Fertility and Sterility, 76, Wyatt KM et al., Determination of total menstrual blood loss, pp125–33, Copyright 2001, with permission from Elsevier; and adapted from Obstetrician & Gynaecologist, 6, Warrilow G et al. Quantification of menstrual blood loss, pp88–92, Copyright 2004 Royal College of Obstetricians and Gynaecologists, with permission from John Wiley and Sons [34, 37]. e. The chart presented by Magnay et al. Reprinted from Fertility and Sterility, 101, Magnay JL et al. Validation of a new menstrual pictogram (superabsorbent polymer-c version) for use with ultraslim towels that contain superabsorbent polymers, pp515–22, Copyright 2014, with permission from Elsevier [5]

Higham J, Reid P. A preliminary investigation of what happens to women complaining of menorrhagia but whose complaint is not substantiated. J Psychosom Obstet Gynaecol. 1995;16:211–4.

Gursel T, Biri A, Kaya Z, Sivaslioglu S, Albayrak M. The frequency of menorrhagia and bleeding disorders in university students. Pediatr Hematol Oncol. 2014;31:467–74.

Waldvogel S, Pedrazzini B, Vaucher P, Bize R, Cornuz J, Tissot J-D, et al. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial. BMC Med. 2012;10:8.

Chimbira TH, Anderson AB, Turnbull A. Relation between measured menstrual blood loss and patient's subjective assessment of loss, duration of bleeding, number of sanitary towels used, uterine weight and endometrial surface area. Br J Obstet Gynaecol. 1980;87:603–9.

Nine studies reported validation of PBAC scoring systems against the alkaline hematin technique. Across these studies, the sensitivity was 58–97%, the specificity was 7.5–95.5%, the positive and negative likelihood ratios were 1.1–13.8 and 0.14–0.56, respectively, and the diagnostic odds ratio was 2.6–52.4. The cut-off score above which the diagnosis of HMB was made ranged from 50 to 185. Several modifications of these PBACs were used in other studies; however, objective confirmation of their validity was not reported. Overall, there was widespread inconsistency of chart design, scoring systems, diagnostic cut-off limits and post-treatment outcome measures.

If you are a current NPS employee, this vacancy may be available on a Loan basis for up to 2 years. Applications are invited from suitable qualified staff.

Sherif N, Goubran H, Hassan A, Burnouf T, El-Ekiaby M. An approach to outreach patients with von Willebrand disease in Egypt by targeting women with heavy menstrual bleeding and/or bleeding symptoms. Haemophilia. 2014;20:238–43.

Menorrhagia is common in patients on oral anticoagulation with vitamin-k-antagonist phenprocoumon. https://www.ismaap.org/studies-publications-detail/menorrhagia-is-common-in-patients-on-oral-anticoagulation-with-vitamin-k-antagonist-phenprocoumon/. Accessed 8 Aug 2018.

Lukes AS, Muse K, Richter HE, Moore KA, Patrick DL. Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding. Curr Med Res Opin. 2010;26:2673–8.

Hald K, Klow NE, Qvigstad E, Istre O. Laparoscopic occlusion compared with embolization of uterine vessels: a randomized controlled trial. Obstet Gynecol. 2007;109:20–7.

Kapur A, Angomchanu R, Dey M. Efficacy of use of long-term, low-dose mifepristone for the treatment of fibroids. J Obstet Gynaecol India. 2016;66:494–8.

Brölmann H, Bongers M, Garza-Leal JG, Gupta J, Veersema S, Quartero R, et al. The FAST-EU trial: 12-month clinical outcomes of women after intrauterine sonography-guided transcervical radiofrequency ablation of uterine fibroids. Gynecol Surg. 2016;13:27–35.

Barr F, Brabin L, Agbaje O. A pictorial chart for managing common menstrual disorders in Nigerian adolescents. Int J Gynaecol Obstet. 1999;66:51–3.

A completed PRISMA checklist for the manuscript is provided as Additional file 3. Please note that the page numbers herein refer to the original submission file and not the final print version.

J.L.M. has received payment for consulting and medical writing services from Bayer AG for this and other work. S.O’B. has received a grant to his institution from Bayer AG for menstrual pictogram research and from Advantage West Midlands (a company involved in the development of an electronic version of premenstrual syndrome charts, pain charts and an alternative menstrual pictogram) for symptometrics. He has received payment from Asarina Pharma for consultancy work and to act as Chief Investigator for a randomized controlled trial on premenstrual syndrome, and from Bayer for consulting services and expert testimony for the licensing of, and lectures on, OC Yaz. He has also been an unpaid Chair for the International Society for Premenstrual Disorders (ISPMD) and has received payment for intellectual property issues unrelated to the work in this manuscript. C.S. and C.G. are full-time employees of Bayer AG.

Dasharathy SS, Mumford SL, Pollack AZ, Perkins NJ, Mattison DR, Wactawski-Wende J, et al. Menstrual bleeding patterns among regularly menstruating women. Am J Epidemiol. 2012;175:536–45.

Pictorial blood loss assessment charts (PBACs) represent the most widely used method to assess menstrual blood loss (MBL) in clinical trials. The aims of this review were to: (1) determine the diagnostic accuracy of PBACs that have been validated against the reference alkaline hematin technique; (2) categorize the pitfalls of using obsolete and nonvalidated charts; (3) provide guidelines for development of a new PBAC or use of an existing chart to measure MBL in clinical trials; and (4) consider the feasibility of using pictorial charts in primary care.

With only two current charts to consider, the choice is limited. However, development of a new pictorial chart can significantly increase the cost and timeline of a clinical trial. The fundamental requirements for the design and validation of a PBAC are listed in Table 3 and should be carefully deliberated before a decision is made. Due consideration should be given whether to include scores for stained sanitary towels, stained tampons, menstrual clots and extraneous blood loss/flooding episodes. Many charts do not incorporate all these components, including some validated methods (Table 4). Other key factors are the construction and design, scoring system, ease and practicality of use and limitations of the method. Each of these elements is discussed below.

To validate any method, it is crucial to have a standard against which the index test can be objectively judged. The AH technique is the most obvious comparator for the PBAC, but it only measures the blood fraction of menstrual discharge. Blood typically comprises approximately 50% of total menstrual volume, although this can vary widely on individual soiled sanitary items, particularly at extremes of menstrual loss [5, 25, 26]. However, feminine towels and tampons absorb all menstrual flow. To maintain parity with AH, validated PBAC icon scores represent blood loss, irrespective of the total fluid volume. In this review, we identify studies that describe the validation of key pictorial charts that have been used to measure MBL. We highlight the diversity in their diagnostic accuracy, the lack of standardization in their application and the pitfalls of using derivative noncertified PBACs. We propose essential criteria to bear in mind when using or validating a pictorial chart for study trials and consider the feasibility of their application in routine clinical practice.

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Kashefi F, Khajehei M, Alavinia M, Golmakani E, Asili J. Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial. Phytother Res. 2015;29:114–9.

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Measurement of MBL by the AH technique is obviously impractical in this setting, but a simple, semi-objective method would be a useful diagnostic tool. It could clarify the patient’s complaint and also influence the choice and expectations of treatment. Historical research data have shown that some women whose MBL has been shown to be normal can be dissuaded from seeking unnecessary therapy for perceived HMB [3, 115, 116]. A fully validated PBAC is theoretically suitable for this purpose, combined with a daily diary to document responses to specific health-related questions throughout the menstrual cycle. This day-to-day record would have the dual purpose of assessing both symptom severity and the impact of perceived or actual HMB on everyday life, which would comply with the National Institute for Health and Care Excellence (NICE) guidelines to assess quality-of-life issues for women with excessive blood loss. Although NICE guidelines do not recommend routine quantitation of MBL, they do acknowledge that further research into indirect measurements of MBL in primary and secondary care is warranted [6].

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Chi C, Huq FY, Kadir RA. Levonorgestrel-releasing intrauterine system for the management of heavy menstrual bleeding in women with inherited bleeding disorders: long-term follow-up. Contraception. 2011;83:242–7.

Shaw RW, Symonds IM, Tamizian O, Chaplain J, Mukhopadhyay S. Randomised comparative trial of thermal balloon ablation and levonorgestrel intrauterine system in patients with idiopathic menorrhagia. Aust N Z J Obstet Gynaecol. 2007;47:335–40.

Warrilow G, Kirkham C, Ismail KM, Wyatt K, Dimmock P, O'Brien S. Quantification of menstrual blood loss. Obstet Gynaecol. 2004;6:88–92.

JLM, conducted the MEDLINE database search, collated data from both Embase and MEDLINE, conducted the analysis, and prepared and edited the manuscript. CG provided statistical support for the analysis and interpretation of data. CS conducted the Embase database search. JLM, SO’B, CG and CS contributed to the conception and design of the review and to the interpretation of the data. All authors reviewed the article critically for intellectual content and approved the final version for publication.

Philipp CS, Faiz A, Dowling NF, Beckman M, Owens S, Ayers C, et al. Development of a screening tool for identifying women with menorrhagia for hemostatic evaluation. Am J Obstet Gynecol. 2008;198:163.e1–8.

Dennie J, Grover S. Assessing heavy periods. https://medicinetoday.com.au/2009/march/patient-handout/assessing-heavy-periods. Accessed 3 Sept 2018. 2009.