Clokie, M. R. J. et al. Transcription of a ‘photosynthetic’ T4-type phage during infection of a marine cyanobacterium. Environ. Microbiol. 8, 827–835 (2006).

Moniruzzaman, M., Gann, E. R. & Wilhelm, S. W. Infection by a giant virus (AaV) induces widespread physiological reprogramming in Aureococcus anophagefferens CCMP1984-A harmful bloom algae. Front. Microbiol. 9, 752 (2018).

Shelford, E. J., Middelboe, M., Møller, E. F. & Suttle, C. A. Virus-driven nitrogen cycling enhances phytoplankton growth. Aquat. Microb. Ecol. 66, 41–46 (2012).

Thomas, R. et al. Acquisition and maintenance of resistance to viruses in eukaryotic phytoplankton populations. Environ. Microbiol. 13, 1412–1420 (2011).

Reimers, A.-M., Knoop, H., Bockmayr, A. & Steuer, R. Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth. Proc. Natl Acad. Sci. USA 114, E6457–E6465 (2017).

Mackenzie, J. J. & Haselkorn, R. Photosynthesis and the development of blue–green algal virus SM-1. Virology 49, 517–521 (1972).

Rosenwasser, S., Ziv, C., Creveld, S. G. van. & Vardi, A. Virocell metabolism: metabolic innovations during host–virus interactions in the ocean. Trends Microbiol. 24, 821–832 (2016).

Stent, G. S. & Maaløe, O. Radioactive phosphorus tracer studies on the reproduction of T4 bacteriophage. Biochim. Biophys. Acta 10, 55–69 (1953).

Kolody, B. C. et al. Diel transcriptional response of a California Current plankton microbiome to light, low iron, and enduring viral infection. ISME J. 13, 2817–2833 (2019).

Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J. & Smith, A. G. Algae acquire vitamin B12 through a symbiotic relationship with bacteria. Nature 438, 90–93 (2005).

Baudoux, A.-C. & Brussaard, C. P. D. Influence of irradiance on virus–algal host interactions. J. Phycol. 44, 902–908 (2008).

You'll need to provide some form of identification when concluding your purchase, but we'd recommend turning directly to Panda support to assist you.

Bratbak, G., Jacobsen, A., Heldal, M., Nagasaki, K. & Thingstad, T. F. Virus production in Phaeocystis pouchetii and its relation to host cell growth and nutrition. Aquat. Microb. Ecol. 16, 1–9 (1998).

Nissimov, J. I. et al. Biochemical diversity of glycosphingolipid biosynthesis as a driver of Coccolithovirus competitive ecology. Environ. Microbiol. 21, 2182–2197 (2019).

Wilson, W. H., Carr, N. G. & Mann, N. H. The effect of phosphate status on the kinetics of cyanophage infection in the oceanic cyanobacterium Synechococcus sp. WH7803. J. Phycol. 32, 506–516 (1996).

Hellweger, F. L. Carrying photosynthesis genes increases ecological fitness of cyanophage in silico. Environ. Microbiol. 11, 1386–1394 (2009).

Mateus, M. D. Bridging the gap between knowing and modeling viruses in marine systems — an upcoming frontier. Front. Mar. Sci. 3, 284 (2017).

Jiao, N. et al. Microbial production of recalcitrant dissolved organic matter: long-term carbon storage in the global ocean. Nat. Rev. Microbiol. 8, 593–599 (2010).

Lønborg, C., Middelboe, M. & Brussaard, C. P. D. Viral lysis of Micromonas pusilla: impacts on dissolved organic matter production and composition. Biogeochemistry 116, 231–240 (2013).

Falkowski, P. G., Fenchel, T. & DeLong, E. F. The microbial engines that drive Earth’s biogeochemical cycles. Science 320, 1034–1039 (2008).

Krupovic, M., Cvirkaite-Krupovic, V., Iranzo, J., Prangishvili, D. & Koonin, E. V. Viruses of archaea: structural, functional, environmental and evolutionary genomics. Virus Res. 244, 181–193 (2018).

Sieradzki, E. T., Ignacio-Espinoza, J. C., Needham, D. M., Fichot, E. B. & Fuhrman, J. A. Dynamic marine viral infections and major contribution to photosynthetic processes shown by regional and seasonal picoplankton metatranscriptomes. Nat. Commun. 10, 1169 (2019).

Koonin, E. V., Makarova, K. S. & Wolf, Y. I. Evolutionary genomics of defense systems in Archaea and Bacteria. Annu. Rev. Microbiol. 71, 233–261 (2017).

Breitbart, M. et al. Genomic analysis of uncultured marine viral communities. Proc. Natl Acad. Sci. USA 99, 14250–14255 (2002).

Malits, A., Christaki, U., Obernosterer, I. & Weinbauer, M. G. Enhanced viral production and virus-mediated mortality of bacterioplankton in a natural iron-fertilized bloom event above the kerguelen plateau. Biogeosciences 11, 6841–6853 (2014).

Weitz, J. S., Li, G., Gulbudak, H., Cortez, M. H. & Whitaker, R. J. Viral invasion fitness across a continuum from lysis to latency. Virus Evol. 5, vez006 (2019).

Zimmerman, A. E. et al. Closely related viruses of the marine picoeukaryotic alga Ostreococcus lucimarinus exhibit different ecological strategies. Environ. Microbiol. 21, 2148–2170 (2019).

This makes it a great choice for people with sensitive skin and eczema [2] or those with dust mite allergies and hay fever.

Allen, M. J. et al. Locus-specific gene expression pattern suggests a unique propagation strategy for a giant algal virus. J. Virol. 80, 7699–7705 (2006).

With millions of visitors each year, our global reach isn't just about numbers - it's about making better choices more accessible to everyone.

You, L., Suthers, P. F. & Yin, J. Effects of Escherichia coli physiology on growth of phage T7 in vivo and in silico. J. Bacteriol. 184, 1888–1894 (2002).

But the Panda memory foam topper uses unique temperature regulation technology to prevent you from ever feeling too hot or clammy.

Claverie, J.-M. & Abergel, C. Mimiviridae: an expanding family of highly diverse large dsDNA viruses infecting a wide phylogenetic range of aquatic eukaryotes. Viruses 10, 506 (2018).

Frada, M. J. et al. Zooplankton may serve as transmission vectors for viruses infecting algal blooms in the ocean. Curr. Biol. 24, 2592–2597 (2014).

Brum, J. R., Hurwitz, B. L., Schofield, O., Ducklow, H. W. & Sullivan, M. B. Seasonal time bombs: dominant temperate viruses affect southern ocean microbial dynamics. ISME J. 10, 437–449 (2016).

So, for example, if you have a king-size mattress, you also need to buy a Panda topper king size, or, if you have a double mattress, you need a Panda double mattress topper.

Jia, Y., Shan, J., Millard, A., Clokie, M. R. J. & Mann, N. H. Light-dependent adsorption of photosynthetic cyanophages to Synechococcus sp. WH7803. FEMS Microbiol. Lett. 310, 120–126 (2010).

Bertilsson, S., Berglund, O., Karl, D. M. & Chisholm, S. W. Elemental composition of marine Prochlorococcus and Synechococcus: implications for the ecological stoichiometry of the sea. Limnol. Oceanogr. 48, 1721–1731 (2003).

Dang, V. T., Howard-Varona, C., Schwenck, S. & Sullivan, M. B. Variably lytic infection dynamics of large Bacteroidetes podovirus phi38:1 against two Cellulophaga baltica host strains. Environ. Microbiol. 17, 4659–4671 (2015).

Fuhrman, J. A., Schwalbach, M. S. & Stingl, U. Proteorhodopsins: an array of physiological roles? Nat. Rev. Microbiol. 6, 488–494 (2008).

Ignacio-Espinoza, J. C. & Sullivan, M. B. Phylogenomics of T4 cyanophages: lateral gene transfer in the ‘core’ and origins of host genes. Environ. Microbiol. 14, 2113–2126 (2012).

We have an affiliate relationship with some manufacturers, where we receive a commission on sales if you click over from our site. This does not affect the purchasing price. In contrast: By using our discount codes, you'll get the best deal possible.

And since the topper is made of high-quality foams and the mattress underneath was a cheaper mattress that's only 18 cm thick, it changed the sleeping experience from average to fantastic.

Waldbauer, J. R. et al. Nitrogen sourcing during viral infection of marine cyanobacteria. Proc. Natl Acad. Sci. USA 116, 15590–15595 (2019). This proteomics study quantitatively tracks nitrogen incorporation during phage infection of Synechococcus, showing that substantial amounts of phage protein nitrogen are acquired from the environment after infection begins and incorporated via de novo amino acid synthesis.

Kim, J.-G. et al. Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea. Proc. Natl Acad. Sci. USA 116, 15645–15650 (2019). This study presents the first reported isolation of viruses infecting widespread marine archaea, demonstrating the continuation of ammonium oxidation activity during infection and a chronic infection strategy distinct from that of the lytic bacteriophage.

Gerringa, L. J. A., de Baar, H. J. W. & Timmermans, K. R. A comparison of iron limitation of phytoplankton in natural oceanic waters and laboratory media conditioned with EDTA. Mar. Chem. 68, 335–346 (2000).

Morimoto, D., Kimura, S., Sako, Y. & Yoshida, T. Transcriptome analysis of a bloom-forming cyanobacterium Microcystis aeruginosa during Ma-LMM01 phage infection. Front. Microbiol. 9, 2 (2018).

Brum, J. R. & Sullivan, M. B. Rising to the challenge: accelerated pace of discovery transforms marine virology. Nat. Rev. Microbiol. 13, 147–159 (2015).

Image

Hurwitz, B. L. & U’Ren, J. M. Viral metabolic reprogramming in marine ecosystems. Curr. Opin. Microbiol. 31, 161–168 (2016).

Evans, C. & Wilson, W. H. Preferential grazing of Oxyrrhis marina on virus-infected Emiliania huxleyi. Limnol. Oceanogr. 53, 2035–2040 (2008).

Sleeping on the Panda topper definitely felt warmer than sleeping on a pocket sprung mattress but at no point did any of our test sleepers feel hot or clammy.

We wouldn’t necessarily say it made the soft mattress firmer but it did manage to completely change the way the sleeping surface felt.

Panda mattress topper reviews on TrustPilot and Amazon are very favourable, with a 4.5-star Amazon rating and over 3500 reviews.

But, for now, it's great to know that the Panda bed topper gives you all the unique properties of memory foam without excessive heat.

Customer service: To contact Panda Life directly for complaints, support, or queries, please e-mail them at info@mypandalife.com, call them on +44 208 935 5380, or visit their live online chat.

Cseke, C. S. & Farkas, G. L. Effect of light on the attachment of cyanophage AS-1 to Anacystis nidulans. J. Bacteriol. 137, 667–669 (1979).

Ou, T., Gao, X. C., Li, S. H. & Zhang, Q. Y. Genome analysis and gene nblA identification of Microcystis aeruginosa myovirus (MaMV-DC) reveal the evidence for horizontal gene transfer events between cyanomyovirus and host. J. Gen. Virol. 96, 3681–3697 (2015).

Kranzler, C. F. et al. Silicon limitation facilitates virus infection and mortality of marine diatoms. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0502-x (2019). Using both cultured isolates and field observations, this study shows that silicon stress can accelerate virus-induced mortality of marine diatoms, potentially promoting nutrient recycling via the viral shunt.

Clasen, J. L. & Elser, J. J. The effect of host Chlorella NC64A carbon:phosphorus ratio on the production of Paramecium bursaria Chlorella Virus-1. Freshw. Biol. 52, 112–122 (2007).

Monier, A. et al. Host-derived viral transporter protein for nitrogen uptake in infected marine phytoplankton. Proc. Natl Acad. Sci. USA 114, E7489–E7498 (2017). This study reports the first nitrogen transport gene in an algal virus isolate and shows that it enables uptake of ammonium as well as organic nitrogen substrates.

Wikner, J., Vallino, J. J., Steward, G. F., Smith, D. C. & Azam, F. Nucleic acids from the host bacterium as a major source of nucleotides for three marine bacteriophages. FEMS Microbiol. Ecol. 12, 237–248 (1993).

(TEP). A sticky, gel-like particle consisting predominantly of acidic polysaccharides that originate from microorganisms and can enhance the aggregation of non-sticky particles in marine and aquatic ecosystems.

Wilson, W. H. et al. Complete genome sequence and lytic phase transcription profile of a Coccolithovirus. Science 309, 1090–1092 (2005).

Derelle, E. et al. Diversity of viruses infecting the green microalga Ostreococcus lucimarinus. J. Virol. 89, 5812–5821 (2015).

Mai-Prochnow, A. et al. ‘Big things in small packages: the genetics of filamentous phage and effects on fitness of their host’. FEMS Microbiol. Rev. 39, 465–487 (2015).

Schieler, B. M. et al. Nitric oxide production and antioxidant function during viral infection of the coccolithophore Emiliania huxleyi. ISME J. 13, 1019–1031 (2019).

Schatz, D. et al. Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms. New Phytol. 204, 854–863 (2014).

Hingamp, P. et al. Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes. ISME J. 7, 1678–1695 (2013).

Coy, S., Gann, E., Pound, H., Short, S. & Wilhelm, S. Viruses of eukaryotic algae: diversity, methods for detection, and future directions. Viruses 10, 487 (2018).

Ledermann, B. et al. Evolution and molecular mechanism of four-electron reducing ferredoxin-dependent bilin reductases from oceanic phages. FEBS J. 285, 339–356 (2018).

Monier, A. et al. Phosphate transporters in marine phytoplankton and their viruses: cross-domain commonalities in viral–host gene exchanges. Environ. Microbiol. 14, 162–176 (2012).

Nature Reviews Microbiology thanks K. Bidle and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Doron, S. et al. Systematic discovery of antiphage defense systems in the microbial pangenome. Science 359, eaar4120 (2018).

Reistetter, E. N. et al. Effects of phosphorus starvation versus limitation on the marine cyanobacterium Prochlorococcus MED4 II: gene expression. Environ. Microbiol. 15, 2129–2143 (2013).

Ziv, C. et al. Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga. Proc. Natl Acad. Sci. USA 113, E1907–E1916 (2016).

Looking for the best deal? We track all discounts, vouchers, and coupons so that you will always get the best price through our site, no matter which mattress or product you end up choosing.

Puxty, R. J., Millard, A. D., Evans, D. J. & Scanlan, D. J. Shedding new light on viral photosynthesis. Photosynth. Res. 126, 71–97 (2015).

Sullivan, M. B. et al. Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments. Environ. Microbiol. 12, 3035–3056 (2010).

Mackinder, L. C. M. et al. A unicellular algal virus, Emiliania huxleyi virus 86, exploits an animal-like infection strategy. J. Gen. Virol. 90, 2306–2316 (2009).

Thompson, L. R., Zeng, Q. & Chisholm, S. W. Gene expression patterns during light and dark infection of Prochlorococcus by cyanophage. PLOS ONE 11, e0165375 (2016).

The company is committed to being vegan-friendly and bird-friendly, protecting animal habitats, keeping habitats chemical-free, and safeguarding existing rainforests through OneTribe [8].

Santini, S. et al. Genome of Phaeocystis globosa virus PgV-16T highlights the common ancestry of the largest known DNA viruses infecting eukaryotes. Proc. Natl Acad. Sci. USA 110, 10800–10805 (2013).

Howard-Varona, C. et al. Regulation of infection efficiency in a globally abundant marine Bacteriodetes virus. ISME J. 11, 284–295 (2017).

Jover, L. F., Effler, T. C., Buchan, A., Wilhelm, S. W. & Weitz, J. S. The elemental composition of virus particles: implications for marine biogeochemical cycles. Nat. Rev. Microbiol. 12, 519–528 (2014).

Kimura, S. et al. Diurnal infection patterns and impact of Microcystis cyanophages in a Japanese pond. Appl. Environ. Microbiol. 78, 5805–5811 (2012).

Abedon, S. T. Phage therapy dosing: the problem(s) with multiplicity of infection (MOI). Bacteriophage 6, e1220348 (2016).

Martiny, A. C. et al. Strong latitudinal patterns in the elemental ratios of marine plankton and organic matter. Nat. Geosci. 6, 279–283 (2013).

Maat, D. S. & Brussaard, C. P. D. Both phosphorus and nitrogen limitation constrain viral proliferation in marine phytoplankton. Aquat. Microb. Ecol. 77, 87–97 (2016).

97% of customers end up completely happy and don't return Panda products, so it may just be the perfect fit for a good night's sleep for you.

Sharma, A. K., Spudich, J. L. & Doolittle, W. F. Microbial rhodopsins: functional versatility and genetic mobility. Trends Microbiol. 14, 463–469 (2006).

We've tried a few Panda London products and didn't experience off-gassing with any of them, but it may happen with your product.

Deng, L. et al. Grazing of heterotrophic flagellates on viruses is driven by feeding behaviour. Environ. Microbiol. Rep. 6, 325–330 (2014).

Edwards, K. F. & Steward, G. F. Host traits drive viral life histories across phytoplankton viruses. Am. Nat. 191, 566–581 (2018).

The ongoing dampness can encourage the growth of mould or bacteria, which can damage your topper and cause health concerns.

Obeng, N., Pratama, A. A. & Elsas, J. D. van. The significance of mutualistic phages for bacterial ecology and evolution. Trends Microbiol. 24, 440–449 (2016).

Van Etten, J. L., Burbank, D. E., Xia, Y. & Meints, R. H. Growth cycle of a virus, PBCV-1, that infects Chlorella-like algae. Virology 126, 117–125 (1983).

Weitz, J. S. et al. A multitrophic model to quantify the effects of marine viruses on microbial food webs and ecosystem processes. ISME J. 9, 1352–1364 (2015).

Zimmerman, A.E., Howard-Varona, C., Needham, D.M. et al. Metabolic and biogeochemical consequences of viral infection in aquatic ecosystems. Nat Rev Microbiol 18, 21–34 (2020). https://doi.org/10.1038/s41579-019-0270-x

The Panda topper is a tad heavy - especially if you're ordering a larger size - but you should still be able to handle it alone.

Allen, M. J., Schroeder, D. C., Donkin, A., Crawfurd, K. J. & Wilson, W. H. Genome comparison of two coccolithoviruses. Virol. J. 3, 15 (2006).

Mistry, B. A., D’Orsogna, M. R. & Chou, T. The effects of statistical multiplicity of infection on virus quantification and infectivity assays. Biophys. J. 114, 2974–2985 (2018).

Needham, D. M. et al. A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators. Proc. Natl Acad. Sci. USA 116, 20574–20583 (2019).

Fischer, M. G., Allen, M. J., Wilson, W. H. & Suttle, C. A. Giant virus with a remarkable complement of genes infects marine zooplankton. Proc. Natl Acad. Sci. USA 107, 19508–19513 (2010).

Gasper, R. et al. Distinct features of cyanophage-encoded T-type phycobiliprotein lyase ΦCpeT: the role of auxiliary metabolic genes. J. Biol. Chem. 292, 3089–3098 (2017).

Lin, X., Ding, H. & Zeng, Q. Transcriptomic response during phage infection of a marine cyanobacterium under phosphorus-limited conditions. Environ. Microbiol. 18, 450–460 (2016).

Vermont, A. I. et al. Virus infection of Emiliania huxleyi deters grazing by the copepod Acartia tonsa. J. Plankton Res. 38, 1194–1205 (2016).

Mahmoudabadi, G., Milo, R. & Phillips, R. The energetic cost of building a virus. Proc. Natl Acad. Sci. USA 114, E4324–E4333 (2017).

Even though the Panda pillow [6] and the Panda bed topper feature memory foam, a synthetic material, Panda as a whole focuses on sustainable and eco-friendly materials.

Thompson, L. R. et al. Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. Proc. Natl Acad. Sci. USA 108, E757–E764 (2011). This paper shows that cyanophages encode a Calvin cycle inhibitor and transaldolase with enzymological properties different from their host homologues, demonstrating the importance of the pentose phosphate pathway during infection.

Puxty, R. J., Evans, D. J., Millard, A. D. & Scanlan, D. J. Energy limitation of cyanophage development: implications for marine carbon cycling. ISME J. 12, 1273–1286 (2018). This study demonstrates that cyanophages modulate expression of photosynthesis-related accessory metabolic genes in response to light intensity, suggesting energy limitation of phage productivity and a basis for diel and seasonal patterns of virus-induced mortality.

Dammeyer, T., Bagby, S. C., Sullivan, M. B., Chisholm, S. W. & Frankenberg-Dinkel, N. Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria. Curr. Biol. 18, 442–448 (2008).

Cheng, Y. S., Labavitch, J. & VanderGheynst, J. S. Organic and inorganic nitrogen impact Chlorella variabilis productivity and host quality for viral production and cell lysis. Appl. Biochem. Biotechnol. 176, 467–479 (2015).

Vardi, A. et al. Host–virus dynamics and subcellular controls of cell fate in a natural coccolithophore population. Proc. Natl Acad. Sci. USA 109, 19327–19332 (2012).

Simba have spent many years researching and developing their sleep products. The mattress topper is no different and uses premium materials, but is it worth its high price?

Heal, K. R. et al. Two distinct pools of B12 analogs reveal community interdependencies in the ocean. Proc. Natl Acad. Sci. USA 114, 364–369 (2017).

Poorvin, L., Rinta-Kanto, J. M., Hutchins, D. A. & Wilhelm, S. W. Viral release of iron and its bioavailability to marine plankton. Limnol. Oceanogr. 49, 1734–1741 (2004).

We’d be a bit careful if you’re sensitive to soft sleeping surfaces and if you tend to sleep quite hot or are a very heavy sweater.

Deeg, C. M., Chow, C. E. T. & Suttle, C. A. The kinetoplastid-infecting Bodo saltans virus (Bsv), a window into the most abundant giant viruses in the sea. eLife 7, e33014 (2018).

Martiny, A. C., Coleman, M. L. & Chisholm, S. W. Phosphate acquisition genes in Prochlorococcus ecotypes: evidence for genome-wide adaptation. Proc. Natl Acad. Sci. USA 103, 12552–12557 (2006).

Kendrick, B. J. et al. Temperature-induced viral resistance in Emiliania huxleyi (Prymnesiophyceae). PLOS ONE 9, e112134 (2014).

Maat, D. S., Crawfurd, K. J., Timmermans, K. R. & Brussaard, C. P. D. Elevated CO2 and phosphate limitation favor Micromonas pusilla through stimulated growth and reduced viral impact. Appl. Environ. Microbiol. 80, 3119–3127 (2014).

Nissimov, J. I. et al. Dynamics of transparent exopolymer particle (TEP) production and aggregation during viral infection of the coccolithophore, Emiliania huxleyi. Environ. Microbiol. 20, 2880–2897 (2018).

Guo, J. et al. Specialized proteomic responses and an ancient photoprotection mechanism sustain marine green algal growth during phosphate limitation. Nat. Microbiol. 3, 781–790 (2018).

Schleyer, G. et al. In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids. Nat. Microbiol. 4, 527–538 (2019).

Lindell, D. et al. Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature 449, 83–86 (2007).

Howard-Varona, C. et al. Multiple mechanisms drive phage infection efficiency in nearly identical hosts. ISME J. 12, 1605–1618 (2018).

This work was supported by the Gordon & Betty Moore Foundation Marine Microbiology Initiative (Award 3305). Additional support was provided by the National Science Foundation Division of Ocean Sciences (NSF-OCE) (Awards 1536989 and 1829831 to M.B.S.), the Simons Foundation (Awards 32910 to S.J. and 402971 to J.R.W.) and the Gordon & Betty Moore Foundation (Awards 3788 to A.Z.W. and 3790 to M.B.S.).

Hyman, P. & Abedon, S. T. in Bacteriophages. Methods and Protocols, Volume 1: Isolation, Characterization, and Interaction (eds Clokie, M. R. J. & Kropinski, A. M.) 175–202 (Humana Press, 2009).

Last updated: 31.10.2023 Reading time: 15 Min. Liked by: 14

Feiner, R. et al. A new perspective on lysogeny: prophages as active regulatory switches of bacteria. Nat. Rev. Microbiol. 13, 641–650 (2015).

Even though you’d probably use a bedsheet on top of your cover, it’s great to know that the Panda cover is fully removable.

Lindell, D., Jaffe, J. D., Johnson, Z. I., Church, G. M. & Chisholm, S. W. Photosynthesis genes in marine viruses yield proteins during host infection. Nature 438, 86–89 (2005).

Luo, E., Aylward, F. O., Mende, D. R. & Delong, E. F. Bacteriophage distributions and temporal variability in the ocean’s interior. mBio 8, e01903–e01917 (2017).

Laber, C. P. et al. Coccolithovirus facilitation of carbon export in the North Atlantic. Nat. Microbiol. 3, 537–547 (2018). This field study marshals an array of evidence to provide some of the first direct measurements of the effects of viral infection on large-scale carbon export in a natural marine ecosystem.

Ahlgren, N. A., Fuchsman, C. A., Rocap, G. & Fuhrman, J. A. Discovery of several novel, widespread, and ecologically distinct marine Thaumarchaeota viruses that encode amoC nitrification genes. ISME J. 13, 618–631 (2018).

Hadas, H., Einav, M., Fishov, I. & Zaritsky, A. Bacteriophage T4 development depends on the physiology of its host Escherichia coli. Microbiology 143, 179–185 (1997).

Stock, C. A., Dunne, J. P. & John, J. G. Global-scale carbon and energy flows through the marine planktonic food web: an analysis with a coupled physical–biological model. Prog. Oceanogr. 120, 1–28 (2014).

Aylward, F. O. et al. Diel cycling and long-term persistence of viruses in the ocean’s euphotic zone. Proc. Natl Acad. Sci. USA 114, 11446–11451 (2017).

Yamada, Y., Tomaru, Y., Fukuda, H. & Nagata, T. Aggregate formation during the viral lysis of a marine diatom. Front. Mar. Sci. 5, 167 (2018).

Ledermann, B., Béjà, O. & Frankenberg-Dinkel, N. New biosynthetic pathway for pink pigments from uncultured oceanic viruses. Environ. Microbiol. 18, 4337–4347 (2016).

Motegi, C. et al. Viral control of bacterial growth efficiency in marine pelagic environments. Limnol. Oceanogr. 54, 1901–1910 (2009).

Kirzner, S., Barak, E. & Lindell, D. Variability in progeny production and virulence of cyanophages determined at the single-cell level. Environ. Microbiol. Rep. 8, 605–613 (2016).

López-Pérez, M., Haro-Moreno, J. M., de la Torre, J. R. & Rodriguez-Valera, F. Novel caudovirales associated with Marine Group I Thaumarchaeota assembled from metagenomes. Environ. Microbiol. 21, 1980–1988 (2019).

Liu, R., Liu, Y., Chen, Y., Zhan, Y. & Zeng, Q. Cyanobacterial viruses exhibit diurnal rhythms during infection. Proc. Natl Acad. Sci. USA 116, 14077–14082 (2019). This paper shows distinct diel-dependent life history traits in three Prochlorococcus phages, and that rhythmic phage transcription is linked to the photosynthetic activity of the host.

Maat, D. S., de Blok, R. & Brussaard, C. P. D. Combined phosphorus limitation and light stress prevent viral proliferation in the phytoplankton species Phaeocystis globosa, but not in Micromonas pusilla. Front. Mar. Sci. 3, 160 (2016).

Bonnain, C., Breitbart, M. & Buck, K. N. The ferrojan horse hypothesis: iron–virus interactions in the ocean. Front. Mar. Sci. 3, 82 (2016).

Gonzalez, J. M. & Suttle, C. A. Grazing by marine nanoflagellates on viruses and virus-sized particles: ingestion and digestion. Mar. Ecol. Prog. Ser. 94, 1–10 (1993).

Kozloff, L. M. & Putnam, F. W. Biochemical studies of virus reproduction: III. The origin of virus phosphorus in the Escherichia coli T6 bacteriophage system. J. Biol. Chem. 182, 229–242 (1950).

Sheyn, U., Rosenwasser, S., Ben-Dor, S., Porat, Z. & Vardi, A. Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean. ISME J. 10, 1742–1754 (2016).

Fridman, S. et al. A myovirus encoding both photosystem I and II proteins enhances cyclic electron flow in infected Prochlorococcus cells. Nat. Microbiol. 2, 1350–1357 (2017).

Grossman, A. R., Schaefer, M. R., Chiang, G. G. & Collier, J. L. The phycobilisome, a light-harvesting complex responsive to environmental conditions. Microbiol. Rev. 57, 725–749 (1993).

Suttle, C. A. & Chen, F. Mechanisms and rates of decay of marine viruses in seawater. Appl. Environ. Microbiol. 58, 3721–3729 (1992).

Gobler, C. J., Hutchins, D. A., Fisher, N. S., Cosper, E. M. & Sanudo-Wilhelmy, S. A. Release and bioavailability of C, N, P, Se, and Fe following viral lysis of a marine chrysophyte. Limnol. Oceanogr. 42, 1492–1504 (1997).

The softer mattress we used is new and in perfect condition, but since it's thinner and softer, it wasn't the right fit for our test sleepers.

Aumont, O., Ethé, C., Tagliabue, A., Bopp, L. & Gehlen, M. PISCES-v2: an ocean biogeochemical model for carbon and ecosystem studies. Geosci. Model. Dev. 8, 2465–2513 (2015).

Nadel, O. et al. Uncultured marine cyanophages encode for active NblA, phycobilisome proteolysis adaptor protein. Preprint at bioRxiv https://doi.org/10.1101/494369 (2018).

Talmy, D. et al. An empirical model of carbon flow through marine viruses and microzooplankton grazers. Environ. Microbiol. 21, 2171–2181 (2019). Using an empirically parameterized model constrained by estimates of prey, predator and viral life history traits, this study calculates carbon flows from primary producers to viruses, grazers and lysates in a marine ecosystem.

Brüssow, H., Canchaya, C. & Hardt, W.-D. Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol. Mol. Biol. Rev. 68, 560–602 (2004).

Of course, a good mattress topper can't fix the problem if pains are due to exercise, bad posture, or lots of desk work.

Bachy, C. et al. Transcriptional responses of the marine green alga Micromonas pusilla and an infecting prasinovirus under different phosphate conditions. Environ. Microbiol. 20, 2898–2912 (2018).

Lawrence, J. et al. Viruses on the menu: the appendicularian Oikopleura dioica efficiently removes viruses from seawater. Limnol. Oceanogr. 63, S244–S253 (2018).

Despite being made of memory foam, the Panda memory foam bamboo mattress topper doesn't have that typical "sinking into the foam" feeling.

Rosenwasser, S. et al. Rewiring host lipid metabolism by large viruses determines the fate of Emiliania huxleyi, a bloom-forming alga in the ocean. Plant Cell 26, 2689–2707 (2014).

Zeng, Q. & Chisholm, S. W. Marine viruses exploit their host’s two-component regulatory system in response to resource limitation. Curr. Biol. 22, 124–128 (2012).

Ecosystems are controlled by ‘bottom-up’ (resources) and ‘top-down’ (predation) forces. Viral infection is now recognized as a ubiquitous top-down control of microbial growth across ecosystems but, at the same time, cell death by viral predation influences, and is influenced by, resource availability. In this Review, we discuss recent advances in understanding the biogeochemical impact of viruses, focusing on how metabolic reprogramming of host cells during lytic viral infection alters the flow of energy and nutrients in aquatic ecosystems. Our synthesis revealed several emerging themes. First, viral infection transforms host metabolism, in part through virus-encoded metabolic genes; the functions performed by these genes appear to alleviate energetic and biosynthetic bottlenecks to viral production. Second, viral infection depends on the physiological state of the host cell and on environmental conditions, which are challenging to replicate in the laboratory. Last, metabolic reprogramming of infected cells and viral lysis alter nutrient cycling and carbon export in the oceans, although the net impacts remain uncertain. This Review highlights the need for understanding viral infection dynamics in realistic physiological and environmental contexts to better predict their biogeochemical consequences.

We've dedicated hundreds of hours to testing mattresses and sleep accessories, and rely on a team of testers of differing weights, temperature preferences, and sleeping positions to evaluate each product.

We may earn a small commission when you click links on our site. This helps our website stay alive, so we can keep reviewing great products and offer you free content. It’s a win-win.

If your Panda product has lived a good, long life and you’d like to dispose of it, Panda will collect the product from your home (free of charge) and repurpose it responsibly.

The uppermost layer of water in a lake or ocean characterized by enough sunlight to support photosynthetic carbon fixation.

Hunter, J. E., Frada, M. J., Fredricks, H. F., Vardi, A. & Van Mooy, B. A. S. Targeted and untargeted lipidomics of Emiliania huxleyi viral infection and life cycle phases highlights molecular biomarkers of infection, susceptibility, and ploidy. Front. Mar. Sci. 2, 81 (2015).

Ankrah, N. Y. D. et al. Phage infection of an environmentally relevant marine bacterium alters host metabolism and lysate composition. ISME J. 8, 1089–1100 (2014). This paper uses metabolomics to quantify redirection of metabolic fluxes during phage infection of a marine α-proteobacterium, and consequent compositional alteration of dissolved material released by lysis.

Kelly, L., Ding, H., Huang, K. H., Osburne, M. S. & Chisholm, S. W. Genetic diversity in cultured and wild marine cyanomyoviruses reveals phosphorus stress as a strong selective agent. ISME J. 7, 1827–1841 (2013).

Slagter, H. A., Gerringa, L. J. A. & Brussaard, C. P. D. Phytoplankton virus production negatively affected by iron limitation. Front. Mar. Sci. 3, 156 (2016).

Adolph, K. W. & Haselkorn, R. Photosynthesis and the development of blue–green algal virus N-1. Virology 47, 370–374 (1972).

Thamatrakoln, K. et al. Light regulation of coccolithophore host–virus interactions. New Phytol. 221, 1289–1302 (2019). Based on photophysiology and biochemical measurements during E. huxleyi viral infection, this study suggests that viral replication is controlled by a light-dependent trade-off between host nucleotide recycling and de novo synthesis.

Rosenwasser, S. et al. Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level. PLOS Pathog. 15, e1007708 (2019).

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Bremer, H. et al. Escherichia Coli and Salmonella: Cellular and Molecular Biology 2nd edn Vol. 2 (eds Neidhardt, F. C. et al.) 1553–1569 (ASM Press, 1996).

Crummett, L. T., Puxty, R. J., Weihe, C., Marston, M. F. & Martiny, J. B. H. The genomic content and context of auxiliary metabolic genes in marine cyanomyoviruses. Virology 499, 219–229 (2016).

If we haven't personally tested a product, please be assured that we invest significant time and energy into scouring the UK market and researching the best recommendations, and we work with a team of sleep experts who review our articles, ensuring that the insights we provide are not only relatable but also reliable.

Ginzburg, D., Padan, E. & Shilo, M. Effect of cyanophage infection on CO2 photoassimilation in Plectonema boryanum. J. Virol. 2, 695–701 (1968).

Waters, R. E. & Chan, A. T. Micromonas pusilla virus: the virus growth cycle and associated physiological events within the host cells; host range mutation. J. Gen. Virol. 63, 199–206 (1982).

Sañudo-Wilhelmy, S. A. et al. Multiple B-vitamin depletion in large areas of the coastal ocean. Proc. Natl Acad. Sci. USA 109, 14041–14045 (2012).

Nicky is an experienced writer and editor with numerous qualifications. As a certified sleep coach, her interests lie in understanding how sleep problems arise from hormonal and environmental issues, particularly as part of stress and anxiety management.

Roux, S. et al. Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses. Nature 537, 689–693 (2016).

Brown, C. M., Lawrence, J. E. & Campbell, D. A. Are phytoplankton population density maxima predictable through analysis of host and viral genomic DNA content? J. Mar. Biol. Assoc. UK 86, 491–498 (2006).

Photosynthetic pigments found in cyanobacteria and the chloroplasts of red algae and glaucophytes that aid in absorption of light energy, particularly at wavelengths that are not well absorbed by chlorophylls or carotenoids.

Intergovernmental Panel on Climate Change. Climate Change 2014: synthesis report. Contribution of Working Groups I, II and III to the fifth assessment report of the Intergovernmental Panel on Climate Change (IPCC, 2014).

Brown, C. M. & Bidle, K. D. Attenuation of virus production at high multiplicities of infection in Aureococcus anophagefferens. Virology 466–467, 71–81 (2014).

Moniruzzaman, M. et al. Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host–virus coevolution. Virology 466–467, 60–70 (2014).

This means it complies with the EU Registration, Evaluation, Authorisation, and restriction of Chemicals regulation (EC) No 1907/2006.

The Panda bamboo topper is conveniently available in a range of British and European mattress sizes to fit (just about) any bed you may come across. 🇬🇧 🇪🇺

Tetu, S. G. et al. Microarray analysis of phosphate regulation in the marine cyanobacterium Synechococcus sp. WH8102. ISME J. 3, 835–849 (2009).

Yoshida, T. et al. Locality and diel cycling of viral production revealed by a 24 h time course cross-omics analysis in a coastal region of Japan. ISME J. 12, 1287–1295 (2018).

Kao, C. C., Green, S., Stein, B. & Golden, S. S. Diel infection of a cyanobacterium by a contractile bacteriophage. Appl. Environ. Microbiol. 71, 4276–4279 (2005).

We have an affiliate relationship with some manufacturers, where we receive a commission on sales if you click over from our site. This does not affect the purchasing price. In contrast: By using our discount codes, you'll get the best deal possible.

Bragg, J. G. & Chisholm, S. W. Modeling the fitness consequences of a cyanophage-encoded photosynthesis gene. PLOS ONE 3, e3550 (2008).

Johns, C. T. et al. The mutual interplay between calcification and coccolithovirus infection. Environ. Microbiol. 21, 1896–1915 (2019).

Brown, C. M., Campbell, D. A. & Lawrence, J. E. Resource dynamics during infection of Micromonas pusilla by virus MpV-Sp1. Environ. Microbiol. 9, 2720–2727 (2007).

You should never soak memory foam, so hand-washing or machine-washing the product is not an option - even if it would fit!

Nicky is an experienced writer and editor with numerous qualifications. As a certified sleep coach, her interests lie in understanding how sleep problems arise from hormonal and environmental issues, particularly as part of stress and anxiety management.

We're a team of sleep enthusiasts and experts. We test hundreds of sleep products - mattresses, pillows, toppers, bed frames, and more - to provide you with the best reviews. Our mission is to help you make the right choice for your sleep.

Middelboe, M., Jørgensen, N. O. G. & Kroer, N. Effects of viruses on nutrient turnover and growth efficiency of noninfected marine bacterioplankton. Appl. Environ. Microbiol. 62, 1991–1997 (1996).

A membrane complex of several proteins, pigments and other cofactors that performs the principal energy conversion reactions of photosynthesis, capturing light energy and converting it into redox potential energy for ATP synthesis and reducing power for reduction of CO2; also known as the photosynthetic reaction centre.

Gao, E.-B., Gui, J.-F. & Zhang, Q.-Y. A novel cyanophage with a cyanobacterial nonbleaching protein A gene in the genome. J. Virol. 86, 236–245 (2012).

Piedade, G. J., Wesdorp, E. M., Montenegro-Borbolla, E., Maat, D. S. & Brussaard, C. P. D. Influence of irradiance and temperature on the virus MpoV-45T infecting the arctic picophytoplankter Micromonas polaris. Viruses 10, 676 (2018).

Mayer, J. A. & Taylor, F. J. R. A virus which lyses the marine nanoflagellate Micromonas pusilla. Nature 281, 299–301 (1979).

Malitsky, S. et al. Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol. New Phytol. 210, 88–96 (2016).

Lindell, D. et al. Transfer of photosynthesis genes to and from Prochlorococcus viruses. Proc. Natl Acad. Sci. USA 101, 11013–11018 (2004).

You'll notice right away that you can sink gently into the topper and get that real feeling of soft, enveloping support. 🤗

Abrahão, J. et al. Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere. Nat. Commun. 9, 749 (2018).

Bryan, D., El-Shibiny, A., Hobbs, Z., Porter, J. & Kutter, E. M. Bacteriophage T4 infection of stationary phase E. coli: life after log from a phage perspective. Front. Microbiol. 7, 1391 (2016).

If you're unsure about whether or not to purchase, we'd recommend reading some of the other Panda topper reviews for peace of mind.

Standard memory foam is known to retain heat, but the cooling gel in the Panda memory foam topper helps regulate your body temperature while you sleep.

Moniruzzaman, M. et al. Virus–host relationships of marine single-celled eukaryotes resolved from metatranscriptomics. Nat. Commun. 8, 16054 (2017).

Pushkarev, A. et al. A distinct abundant group of microbial rhodopsins discovered using functional metagenomics. Nature 558, 595–599 (2018).

Middelboe, M. & Jørgensen, N. O. G. Viral lysis of bacteria: an important source of dissolved amino acids and cell wall compounds. J. Mar. Biol. Assoc. UK 86, 605–612 (2006).

Pasulka, A. L. et al. Interrogating marine virus–host interactions and elemental transfer with BONCAT and nanoSIMS-based methods. Environ. Microbiol. 20, 671–692 (2018).

Ma, X., Coleman, M. L. & Waldbauer, J. R. Distinct molecular signatures in dissolved organic matter produced by viral lysis of marine cyanobacteria. Environ. Microbiol. 20, 3001–3011 (2018).

Moore, J. K., Doney, S. C. & Lindsay, K. Upper ocean ecosystem dynamics and iron cycling in a global three-dimensional model. Glob. Biogeochem. Cycles 18, GB4028 (2004).

Nissimov, J. I., Napier, J. A., Allen, M. J. & Kimmance, S. A. Intragenus competition between coccolithoviruses: an insight on how a select few can come to dominate many. Environ. Microbiol. 18, 133–145 (2016).

Puxty, R. J., Millard, A. D., Evans, D. J. & Scanlan, D. J. Viruses inhibit CO2 fixation in the most abundant phototrophs on Earth. Curr. Biol. 26, 1585–1589 (2016).

Schvarcz, C. R. & Steward, G. F. A giant virus infecting green algae encodes key fermentation genes. Virology 518, 423–433 (2018).

Roux, S. et al. Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics. eLife 3, e03125 (2014).

Maat, D. S. et al. Characterization and temperature dependence of arctic Micromonas polaris viruses. Viruses 9, 134 (2017).

Shah, V., Chang, B. X. & Morris, R. M. Cultivation of a chemoautotroph from the SUP05 clade of marine bacteria that produces nitrite and consumes ammonium. ISME J. 11, 263–271 (2017).