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IVchord in C major

Methods: Twelve paraplegic patients were enrolled in a double blind cross over intravenous trial of 4-Aminopyridine (4-AP). Thirty milligrams of 4-AP or placebo were administered over a 2 h period. Patients were serially examined during and after the infusion clinically for pain, sensorimotor function, hypertonicity and motor control using electromyography (EMG). Samples of blood and cerebrospinal fluid (CSF) were also analyzed at similar intervals.

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Chord identifier

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Donovan, W., Halter, J., Graves, D. et al. Intravenous infusion of 4-AP in chronic spinal cord injured subjects. Spinal Cord 38, 7–15 (2000). https://doi.org/10.1038/sj.sc.3100931

Objective: To determine the efficacy of this drug in the treatment of spinal cord injured (SCI) patients for neurologic impairment, pain and spasticity.

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Results: Despite penetration of 4-AP into the CSF, no significant differences were noted in the clinical and EMG parameters at the times measured. Individual changes in sensory function were reported by some patients in both the placebo and 4-AP trials, however mean values were not robust. Frequently, patients complained of unpleasant symptoms during the 4-AP infusion.

Conclusion: The intravenous route may not be the best way to administer this drug as no short term benefits were observed.