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9 Apr 2024 — IngMar Medical has released Aurora, a medical simulation manikin used to train clinicians in all forms of ventilation, according to a company ...
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6 Mar 2024 — High quality Clinics / Hospitals SpO2 Adapter Cable - 2021406-001 Compatible For GE Healthcare from China, China's leading SpO2 Sensor Cable ...
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Elevated lipogenesis is an important metabolic hallmark of rapidly proliferating tumor such as endometrial carcinoma (EC). The sterol regulatory element-binding protein 1 (SREBP1) is a master regulator of lipogenesis and involved in EC proliferation. BF175 is a novel chemical inhibitor of SREBP pathway, and has shown potent anti-lipogenic effects. However, the effect of BF175 on EC cells are yet to be determined. In the present study, we found that BF175 decreased cell viability, colony formation and migratory capacity, inducing autophagy and mitochondrial related apoptosis in EC cell line AN3CA. Z-VAD-FMK partially attenuated the effect of BF175 on AN3CA. In addition, BF175 significantly downregulated SREBPs and their downstream genes. The levels of free fatty acids and total cholesterol were also inhibited. Microarray analysis suggested BF175 treatment obviously affected lipid metabolic pathways in EC. Taken together, we validated BF175 exhibited anti-tumor activity by targeting SREBP-dependent lipogenesis and inducing apoptosis which mitochondrial pathway involved in, suggesting that it's potential as a novel therapeutic reagent for EC.
zw-08-14-h-s-430-500 - The ZW series is a through-hole PCB header system that allows designers to create part numbers for specific, non-standard board ...
They have a nice environment to work. Cons: The starter hour paid is $12.50 wich I think at this point should start at least at $15.00.